The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Role of the Mouse ank Gene in Control of Tissue Calcification and Arthritis
Abstract
Mutation at the mouse progressive ankylosis ( ank ) locus causes a generalized, progressive form of arthritis accompanied by mineral deposition, formation of bony outgrowths, and joint destruction. Here, we show that the ank locus encodes a multipass transmembrane protein (ANK) that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. A highly conserved gene is present in humans and other vertebrates. These results identify ANK-mediated control of pyrophosphate levels as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals.
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Cites
Effect of condensed phosphates on calcification of chick embryo femurs in tissue culture
Fleisch, H., Straumann, F., Schenk, R., Bisaz, S., & Allgower, M. (1966) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1966.211.3.821 · Cited by 95
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Murshed, M., Harmey, D., Millán, J. L., McKee, M. D., & Karsenty, G. (2005) · Genes & Development · doi:10.1101/gad.1276205 · Cited by 601
The program of androgen-responsive genes in neoplastic prostate epithelium
Nelson, P. S., Clegg, N., Arnold, H., Ferguson, C., Bonham, M., White, J., Hood, L., & Lin, B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182376299 · Cited by 482
Acidocalcisomes ? conserved from bacteria to man
Docampo, R., de Souza, W., Miranda, K., Rohloff, P., & Moreno, S. N. J. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1097 · Cited by 468
Bisphosphonates: An Update on Mechanisms of Action and How These Relate to Clinical Efficacy
RUSSELL, R. G. G., XIA, Z., DUNFORD, J. E., OPPERMANN, U., KWAASI, A., HULLEY, P. A., KAVANAGH, K. L., TRIFFITT, J. T., LUNDY, M. W., PHIPPS, R. J., et al. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1402.089 · Cited by 391
Metadata
- Authors
- Ho, A. M., Johnson, M. D., & Kingsley, D. M.
- Venue
- Science
- Published
- 2000-07-14
- Volume
- 289
- Issue
- 5477
- Pages
- 265-270
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2000413455
- Cited by
- 652
- References
- 1
- FWCI
- 22.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ho, A. M., Johnson, M. D., & Kingsley, D. M. (2000). Role of the Mouse ank Gene in Control of Tissue Calcification and Arthritis. Science. https://doi.org/10.1126/science.289.5477.265
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
