The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
An Anti-Apoptotic Role for the p53 Family Member, p73, During Developmental Neuron Death
Abstract
p53 plays an essential pro-apoptotic role, a function thought to be shared with its family members p73 and p63. Here, we show that p73 is primarily present in developing neurons as a truncated isoform whose levels are dramatically decreased when sympathetic neurons apoptose after nerve growth factor (NGF) withdrawal. Increased expression of truncated p73 rescues these neurons from apoptosis induced by NGF withdrawal or p53 overexpression. In p73–/– mice, all isoforms of p73 are deleted and the apoptosis of developing sympathetic neurons is greatly enhanced. Thus, truncated p73 is an essential anti-apoptotic protein in neurons, serving to counteract the pro-apoptotic function of p53.
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Citations
Cites
p73 is a human p53-related protein that can induce apoptosis
Jost, C. A., Marin, M. C., & Jr, W. G. K. (1997) · Nature · doi:10.1038/38298 · Cited by 948
Cited by
p63 and p73: Roles in Development and Tumor Formation
Moll, U. M., & Slade, N. (2004) · Molecular Cancer Research · doi:10.1158/1541-7786.371.2.7 · Cited by 486
p63 and p73, the ancestors of p53
Dotsch, V., Bernassola, F., Coutandin, D., Candi, E., & Melino, G. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004887 · Cited by 326
Complex controls: the role of alternative promoters in mammalian genomes
Landry, J.-R., Mager, D. L., & Wilhelm, B. T. (2003) · Trends in Genetics · doi:10.1016/j.tig.2003.09.014 · Cited by 331
Genetic Control of Programmed Cell Death During Animal Development
Conradt, B. (2009) · Annual Review of Genetics · doi:10.1146/annurev.genet.42.110807.091533 · Cited by 173
The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?
Fielder, E., von Zglinicki, T., & Jurk, D. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-161221 · Cited by 126
Metadata
- Authors
- Pozniak, C. D., Radinovic, S., Yang, A., McKeon, F., Kaplan, D. R., & Miller, F. D.
- Venue
- Science
- Published
- 2000-07-14
- Volume
- 289
- Issue
- 5477
- Pages
- 304-306
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1997222931
- Cited by
- 465
- References
- 1
- FWCI
- 16.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pozniak, C. D., Radinovic, S., Yang, A., McKeon, F., Kaplan, D. R., & Miller, F. D. (2000). An Anti-Apoptotic Role for the p53 Family Member, p73, During Developmental Neuron Death. Science. https://doi.org/10.1126/science.289.5477.304
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
