The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Asef, a Link Between the Tumor Suppressor APC and G-Protein Signaling
Abstract
The adenomatous polyposis coli gene ( APC ) is mutated in familial adenomatous polyposis and in sporadic colorectal tumors. Here the APC gene product is shown to bind through its armadillo repeat domain to a Rac-specific guanine nucleotide exchange factor (GEF), termed Asef. Endogenous APC colocalized with Asef in mouse colon epithelial cells and neuronal cells. Furthermore, APC enhanced the GEF activity of Asef and stimulated Asef-mediated cell flattening, membrane ruffling, and lamellipodia formation in MDCK cells. These results suggest that the APC-Asef complex may regulate the actin cytoskeletal network, cell morphology and migration, and neuronal function.
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Cites
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Cited by
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
Rossman, K. L., Der, C. J., & Sondek, J. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1587 · Cited by 1,697
Linking Colorectal Cancer to Wnt Signaling
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Caught up in a Wnt storm: Wnt signaling in cancer
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Regulation of Small GTPases by GEFs, GAPs, and GDIs
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Metadata
- Authors
- Kawasaki, Y., Senda, T., Ishidate, T., Koyama, R., Morishita, T., Iwayama, Y., Higuchi, O., & Akiyama, T.
- Venue
- Science
- Published
- 2000-08-18
- Volume
- 289
- Issue
- 5482
- Pages
- 1194-1197
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2081012321
- Cited by
- 349
- References
- 28
- FWCI
- 8.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kawasaki, Y., Senda, T., Ishidate, T., Koyama, R., Morishita, T., Iwayama, Y., Higuchi, O., & Akiyama, T. (2000). Asef, a Link Between the Tumor Suppressor APC and G-Protein Signaling. Science. https://doi.org/10.1126/science.289.5482.1194
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
