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Differential Clustering of CD4 and CD3ζ During T Cell Recognition
Abstract
Whereas T helper cells recognize peptide–major histocompatibility complex (MHC) class II complexes through their T cell receptors (TCRs), CD4 binds to an antigen-independent region of the MHC. Using green fluorescent protein–tagged chimeras and three-dimensional video microscopy, we show that CD4 and TCR-associated CD3ζ cluster in the interface coincident with increases in intracellular calcium. Signaling-, costimulation-, and cytoskeleton-dependent processes then stabilize CD3ζ in a single cluster at the center of the interface, while CD4 moves to the periphery. Thus, the CD4 coreceptor may serve primarily to “boost” recognition of ligand by the TCR and may not be required once activation has been initiated.
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Citations
Cited by
T cell migration, search strategies and mechanisms
Krummel, M. F., Bartumeus, F., & Gérard, A. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.16 · Cited by 423
Self-citationAn Enigmatic Tail of CD28 Signaling
Boomer, J. S., & Green, J. M. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002436 · Cited by 283
Arana, E., Vehlow, A., Harwood, N. E., Vigorito, E., Henderson, R., Turner, M., Tybulewicz, V. L. J., & Batista, F. D. (2008) · Immunity · doi:10.1016/j.immuni.2007.12.003 · Cited by 156
Differential role of lipid rafts in the functions of CD4+ and CD8+ human T lymphocytes with aging
Larbi, A., Dupuis, G., Khalil, A., Douziech, N., Fortin, C., & Fülöp, T. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2005.08.016 · Cited by 126
Immunological synapse and microclusters: the site for recognition and activation of T cells
Saito, T., & Yokosuka, T. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.03.014 · Cited by 124
Fischer, H. J., Schweingruber, N., Lühder, F., & Reichardt, H. M. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.04.001 · Cited by 34
Metadata
- Authors
- Krummel, M. F., Sjaastad, M. D., Wülfing, C., & Davis, M. M.
- Venue
- Science
- Published
- 2000-08-25
- Volume
- 289
- Issue
- 5483
- Pages
- 1349-1352
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2043893491
- Cited by
- 366
- References
- 0
- FWCI
- 11.59
- Type
- journal article
- Language
- en
- Open access
- closed
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
