An Enigmatic Tail of CD28 Signaling

Boomer, J. S.; Green, J. M.

doi:10.1101/cshperspect.a002436

Cited by 283T-cell and B-cell ImmunologySignaling Pathways in DiseaseNF-κB Signaling Pathways

An Enigmatic Tail of CD28 Signaling

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Boomer, J. S., Green, J. M.·2010·Cold Spring Harbor Perspectives in Biology

DOI 10.1101/cshperspect.a002436PMC PMC2908766

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Abstract

CD28 costimulation regulates a wide range of cellular processes, from proliferation and survival to promoting the differentiation of specialized T-cell subsets. Since first being identified over 20 years ago, CD28 has remained a subject of intense study because of its profound consequences on T cell function and its potential for therapeutic manipulation. In this review we highlight the signaling cascades initiated by the major signaling motifs in CD28, focusing on PI-3 kinase-dependent and -independent pathways and how these are linked to specific cellular outcomes. Recent studies using gene targeted knockin mice have clarified the relative importance of these motifs on in vivo immune responses; however, much remains to be elucidated. Understanding the mechanism behind costimulation holds great potential for development of new clinically relevant reagents, a fact beginning to be realized with the advent of drugs that prevent CD28 ligation and signaling.

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CD28 signaling is connected to higher Δ133p53 protein, because NF-κB and its downstream mTOR activation may suppress autophagy.
“This finding links CD28 function to Δ133p53 upregulation at the protein level, since NF-κB and its activation of mTOR, a major downstream pathway activated by the CD28 signaling, may repress autophagy (36)(37)(38)(39)(40).”
From p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes (2013) · cites this paper as [36]

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Authors: Boomer, J. S., & Green, J. M.
Affiliations: Washington University in St. Louis (US)
Corresponding author: Green, J. M.
ORCID: Green, J. M.
Venue: Cold Spring Harbor Perspectives in Biology
Publisher: Cold Spring Harbor Laboratory
Published: 2010-06-09
Volume: 2
Issue: 8
Pages: a002436-a002436
ISSN: 1943-0264 (ISSN-L)
DOI: 10.1101/cshperspect.a002436
PMC: PMC2908766
OpenAlex: W2160717085
Cited by: 283
References: 217
Citations by year: 2026: 15 · 2025: 18 · 2024: 22 · 2023: 22 · 2022: 23 · 2021: 17 · 2020: 29 · 2019: 17 · 2018: 29 · 2017: 18 · 2016: 11 · 2015: 24 · 2014: 14 · 2013: 12 · 2012: 8
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Cold Spring Harbor Perspectives in Biology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (HL062683, R01HL062683)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: CD28, costimulation, T cell signaling, PI3-kinase, T cell proliferation, T cell survival, T cell differentiation, immune regulation
MeSH terms: Animals, Cell Line, Humans, Immune System, Lymphocyte Activation, Mice, Transgenic, Models, Biological, Receptors, Antigen, T-Cell, T-Lymphocytes, Signal Transduction, CD28 Antigens, Phosphatidylinositol 3-Kinases, Amino Acid Motifs, Protein Interaction Mapping, Mice

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An Enigmatic Tail of CD28 Signaling

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