The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice
Open accessAbstract
A20 is a cytoplasmic zinc finger protein that inhibits nuclear factor κB (NF-κB) activity and tumor necrosis factor (TNF)–mediated programmed cell death (PCD). TNF dramatically increases A20 messenger RNA expression in all tissues. Mice deficient for A20 develop severe inflammation and cachexia, are hypersensitive to both lipopolysaccharide and TNF, and die prematurely. A20-deficient cells fail to terminate TNF-induced NF-κB responses. These cells are also more susceptible than control cells to undergo TNF-mediated PCD. Thus, A20 is critical for limiting inflammation by terminating TNF-induced NF-κB responses in vivo.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A20 KO mice are born cachectic and die within 4–5 weeks of birth mainly from unfettered liver inflammation, which shows A20’s high rank in the hierarchy of the liver physiologic anti-inflammatory armamentarium (21).”
From A20 promotes liver regeneration by decreasing SOCS3 expression to enhance IL-6/STAT3 proliferative signals (2013) · cites this paper as [21]
In the citing paper
“TNFAIP3 is a deubiquitinating enzyme and inhibits TNF-mediated apoptosis38, whereas HMOX1 is involved in the initial step of haem degradation and has been shown to have antioxidant and anti-inflammatory effects38,39.”
From Design and testing of a humanized porcine donor for xenotransplantation (2023) · cites this paper as [38]
In the citing paper
“Although overlapping in their anti-apoptotic activities, TNFAIP3 and HMOX1 achieve this outcome by their unique biological functions and dampen inflammation under distinct circumstances.”
From Design and testing of a humanized porcine donor for xenotransplantation (2023) · cites this paper as [38]
Citations
Cites
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047
Wang, C.-Y., Mayo, M., Korneluk, R., Goeddel, D., & Baldwin, A. (1998) · Science · doi:10.1126/science.281.5383.1680 · Cited by 2,950
TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB
Wang, C.-Y., Mayo, M. W., & Baldwin, A. S. (1996) · Science · doi:10.1126/science.274.5288.784 · Cited by 2,586
Suppression of TNF-α-Induced Apoptosis by NF-κB
Antwerp, D. J. V., Martin, S. J., Kafri, T., Green, D. R., & Verma, I. M. (1996) · Science · doi:10.1126/science.274.5288.787 · Cited by 2,581
Liu, Z.-G., Hsu, H., Goeddel, D. V., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81375-6 · Cited by 1,937
NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway
Sun, S., Ganchi, P. A., Ballard, D. W., & Greene, W. C. (1993) · Science · doi:10.1126/science.8096091 · Cited by 1,108
Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice.
Rudolph, D., Yeh, W., Wakeham, A. C., Rudolph, B., Nallainathan, D., Potter, J., Elia, A., & Mak, T. W. (2000) · PubMed Central · Cited by 518
Severe liver degeneration and lack of NF-κ B activation in NEMO/IKKγ-deficient mice
Rudolph, D., Yeh, W.-C., Wakeham, A., Rudolph, B., Nallainathan, D., Potter, J., Elia, A. J., & Mak, T. W. (2000) · Genes & Development · doi:10.1101/gad.14.7.854 · Cited by 479
Beg, A. A., Sha, W. C., Bronson, R. T., & Baltimore, D. (1995) · Genes & Development · doi:10.1101/gad.9.22.2736 · Cited by 466
Recruitment of the IKK Signalosome to the p55 TNF Receptor
Zhang, S. Q., Kovalenko, A., Cantarella, G., & Wallach, D. (2000) · Immunity · doi:10.1016/s1074-7613(00)80183-1 · Cited by 456
The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity.
Opipari, A. W., Hu, H., Yabkowitz, R., & Dixit, V. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42292-2 · Cited by 434
The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein.
Opipari, A. W., Boguski, M. S., & Dixit, V. M. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77165-2 · Cited by 419
Song, H. Y., Rothe, M., & Goeddel, D. V. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6721 · Cited by 414
Heyninck, K., VALCK, D. D., Berghe, W. V., Criekinge, W. V., Contreras, R., Fiers, W., Haegeman, G., & Beyaert, R. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.7.1471 · Cited by 295
A20 Blocks Endothelial Cell Activation through a NF-κB-dependent Mechanism
Cooper, J. T., Stroka, D. M., Brostjan, C., Palmetshofer, A., Bach, F. H., & Ferran, C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.18068 · Cited by 247
A20 zinc finger protein inhibits TNF and IL-1 signaling
Jäättelä, M., Mouritzen, H., Elling, F., & Bastholm, L. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.3.1166 · Cited by 242
Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways.
Wong, G. H., & Goeddel, D. V. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.4.1751 · Cited by 196
Lymphoid expression and regulation of A20, an inhibitor of programmed cell death.
Tewari, M., Wolf, F. W., Seldin, M. F., O'Shea, K. S., Dixit, V. M., & Turka, L. A. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.4.1699 · Cited by 99
Constitutive synthesis of tumor necrosis factor in the thymus.
Giroir, B. P., Brown, T., & Beutler, B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.11.4864 · Cited by 95
Research works printed but not linked: 1
- Supplemental material is available at www.sciencemag.org/feature/data/1053996.shl
Cited by
Sorted by citations
Hayden, M. S., & Ghosh, S. (2004) · Genes & Development · doi:10.1101/gad.1228704 · Cited by 3,842
The TNF and TNF Receptor Superfamilies
Locksley, R. M., Killeen, N., & Lenardo, M. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00237-9 · Cited by 3,650
Tumor necrosis factor signaling
Wajant, H., Pfizenmaier, K., & Scheurich, P. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401189 · Cited by 2,422
Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study
Yu, H., Lin, L., Zhang, Z., Zhang, H., & Hu, H. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00312-6 · Cited by 2,329
Necroptosis, pyroptosis and apoptosis: an intricate game of cell death
Bertheloot, D., Latz, E., & Franklin, B. S. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00630-3 · Cited by 2,297
Metadata
- Authors
- Lee, E. G., Boone, D. L., Chai, S., Libby, S. L., Chien, M., Lodolce, J. P., & Ma, A.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Lee, Eric G.
- Boone, David L.
- Ma, Averil
- Venue
- Science
- Published
- 2000-09-29
- Volume
- 289
- Issue
- 5488
- Pages
- 2350-2354
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3582399
- OpenAlex
- W1993936200
- Cited by
- 1,409
- References
- 19
- Citations by year
- 2026: 21 · 2025: 27 · 2024: 43 · 2023: 33 · 2022: 44 · 2021: 53 · 2020: 57 · 2019: 65 · 2018: 46 · 2017: 68 · 2016: 75 · 2015: 76 · 2014: 72 · 2013: 88 · 2012: 69
- FWCI
- 12.77
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM007183, 5T32 GM-07183, T32GM007839, T32GM07839)
- National Institute of Allergy and Infectious Diseases (R01AI045860)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK052751)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- A20, NF-κB, TNF-α, programmed cell death, TNF-induced cell death, inflammation, cachexia, zinc finger proteins
- MeSH terms
- NF-KappaB Inhibitor alpha, Tumor Necrosis Factor alpha-Induced Protein 3, Animals, Cachexia, Cells, Cultured, Cysteine Endopeptidases, DNA, DNA-Binding Proteins, Fibroblasts, Inflammation, Interleukin-1, Intestines, Kidney, Lipopolysaccharides, Liver, Nuclear Proteins, Phosphorylation, Proteins, Skin, T-Lymphocytes, Tumor Necrosis Factor-alpha, NF-kappa B, Zinc Fingers, Apoptosis, Gene Targeting, I-kappa B Proteins, Intracellular Signaling Peptides and Proteins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
