The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Potent Analgesic Effects of GDNF in Neuropathic Pain States
Abstract
Neuropathic pain arises as a debilitating consequence of nerve injury. The etiology of such pain is poorly understood, and existing treatment is largely ineffective. We demonstrate here that glial cell line–derived neurotrophic factor (GDNF) both prevented and reversed sensory abnormalities that developed in neuropathic pain models, without affecting pain-related behavior in normal animals. GDNF reduces ectopic discharges within sensory neurons after nerve injury. This may arise as a consequence of the reversal by GDNF of the injury-induced plasticity of several sodium channel subunits. Together these findings provide a rational basis for the use of GDNF as a therapeutic treatment for neuropathic pain states.
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Cites
Ho Kim, S., & Mo Chung, J. (1992) · Pain · doi:10.1016/0304-3959(92)90041-9 · Cited by 3,069
Cited by
Mechanisms of neuropathic pain
Campbell, J. N., & Meyer, R. A. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.021 · Cited by 1,471
Models and Mechanisms of Hyperalgesia and Allodynia
Sandkühler, J. (2009) · Physiological Reviews · doi:10.1152/physrev.00025.2008 · Cited by 1,148
The Role of Voltage-Gated Sodium Channels in Pain Signaling
Bennett, D. L., Clark, A. J., Huang, J., Waxman, S. G., & Dib-Hajj, S. D. (2019) · Physiological Reviews · doi:10.1152/physrev.00052.2017 · Cited by 730
Self-citationAxon-Glial Signaling and the Glial Support of Axon Function
Nave, K.-A., & Trapp, B. D. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094309 · Cited by 658
Austin, P. J., & Moalem-Taylor, G. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.08.013 · Cited by 607
Metadata
- Authors
- Boucher, T. J., Okuse, K., Bennett, D. L. H., Munson, J. B., Wood, J. N., & McMahon, S. B.
- Venue
- Science
- Published
- 2000-10-06
- Volume
- 290
- Issue
- 5489
- Pages
- 124-127
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2071595010
- Cited by
- 519
- References
- 1
- FWCI
- 17.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Boucher, T. J., Okuse, K., Bennett, D. L. H., Munson, J. B., Wood, J. N., & McMahon, S. B. (2000). Potent Analgesic Effects of GDNF in Neuropathic Pain States. Science. https://doi.org/10.1126/science.290.5489.124
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
