Mechanisms of neuropathic pain
Open accessAbstract
Neuropathic pain refers to pain that originates from pathology of the nervous system. Diabetes, infection (herpes zoster), nerve compression, nerve trauma, "channelopathies," and autoimmune disease are examples of diseases that may cause neuropathic pain. The development of both animal models and newer pharmacological strategies has led to an explosion of interest in the underlying mechanisms. Neuropathic pain reflects both peripheral and central sensitization mechanisms. Abnormal signals arise not only from injured axons but also from the intact nociceptors that share the innervation territory of the injured nerve. This review focuses on how both human studies and animal models are helping to elucidate the mechanisms underlying these surprisingly common disorders. The rapid gain in knowledge about abnormal signaling promises breakthroughs in the treatment of these often debilitating disorders.
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Long-term nerve compression can contribute to the development of neuropathic pain.
“Long-term nerve compression can also contribute to the development of neuropathic pain (Campbell and Meyer, 2006; Yalcin et al., 2014).”
From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Campbell and Meyer, 2006
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- Authors
- Campbell, J. N., & Meyer, R. A.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Campbell, James N.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2006-10
- Volume
- 52
- Issue
- 1
- Pages
- 77-92
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC1810425
- OpenAlex
- W2066796908
- Cited by
- 1,471
- References
- 1
- Citations by year
- 2026: 59 · 2025: 75 · 2024: 83 · 2023: 77 · 2022: 69 · 2021: 98 · 2020: 92 · 2019: 86 · 2018: 83 · 2017: 73 · 2016: 66 · 2015: 69 · 2014: 76 · 2013: 63 · 2012: 69
- FWCI
- 7.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (NS-014447, NS-041269, R01NS041269, R01NS014447)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- neuropathic pain, pain mechanisms, peripheral sensitization, central sensitization, nociceptors, animal models of neuropathic pain, diabetic neuropathy, herpes zoster, nerve injury, channelopathies, autoimmune neuropathy, pain pharmacology
- MeSH terms
- Animals, Disease Models, Animal, Humans, Hyperalgesia, Models, Biological, Nervous System Diseases, Neuralgia, Pain Measurement, Peripheral Nerves
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