The DOI matches its Crossref record.
A Myosin I Isoform in the Nucleus
Abstract
A nuclear isoform of myosin I β that contains a unique 16–amino acid amino-terminal extension has been identified. An affinity-purified antibody to the 16–amino acid peptide demonstrated nuclear staining. Confocal and electron microscopy revealed that nuclear myosin I β colocalized with RNA polymerase II in an α-amanitin– and actinomycin D–sensitive manner. The antibody coimmunoprecipitated RNA polymerase II and blocked in vitro RNA synthesis. This isoform of myosin I β appears to be in a complex with RNA polymerase II and may affect transcription.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
The nuclear lamina comes of age
Gruenbaum, Y., Margalit, A., Goldman, R. D., Shumaker, D. K., & Wilson, K. L. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1550 · Cited by 834
Dynamics of Single mRNPs in Nuclei of Living Cells
Shav-Tal, Y., Darzacq, X., Shenoy, S. M., Fusco, D., Janicki, S. M., Spector, D. L., & Singer, R. H. (2004) · Science · doi:10.1126/science.1099754 · Cited by 494
Nuclear actin and myosin I are required for RNA polymerase I transcription
Philimonenko, V. V., Zhao, J., Iben, S., Dingová, H., Kyselá, K., Kahle, M., Zentgraf, H., Hofmann, W. A., de Lanerolle, P., Hozák, P., et al. (2004) · Nature Cell Biology · doi:10.1038/ncb1190 · Cited by 398
Self-citationActin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II
Hofmann, W. A., Stojiljkovic, L., Fuchsova, B., Vargas, G. M., Mavrommatis, E., Philimonenko, V., Kysela, K., Goodrich, J. A., Lessard, J. L., Hope, T. J., et al. (2004) · Nature Cell Biology · doi:10.1038/ncb1182 · Cited by 357
Self-citationNonthermal ATP-dependent fluctuations contribute to the in vivo motion of chromosomal loci
Weber, S. C., Spakowitz, A. J., & Theriot, J. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119505109 · Cited by 344
Metadata
- Authors
- Pestic-Dragovich, L., Stojiljkovic, L., Philimonenko, A. A., Nowak, G., Ke, Y., Settlage, R. E., Shabanowitz, J., Hunt, D. F., Hozak, P., & de Lanerolle, P.
- Venue
- Science
- Published
- 2000-10-13
- Volume
- 290
- Issue
- 5490
- Pages
- 337-341
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1983473532
- Cited by
- 243
- References
- 0
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A Myosin I Isoform in the Nucleus. https://app.cochat.ai/papers/10.1126/science.290.5490.337
- The paper
- Pestic-Dragovich, L., Stojiljkovic, L., Philimonenko, A. A., Nowak, G., Ke, Y., Settlage, R. E., Shabanowitz, J., Hunt, D. F., Hozak, P., & de Lanerolle, P. (2000). A Myosin I Isoform in the Nucleus. Science. https://doi.org/10.1126/science.290.5490.337
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
