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Plasma Membrane Compartmentalization in Yeast by Messenger RNA Transport and a Septin Diffusion Barrier
Abstract
Asymmetric localization of proteins plays a key role in many cellular processes, including cell polarity and cell fate determination. Using DNA microarray analysis, we identified a plasma membrane protein-encoding mRNA (IST2) that is transported to the bud tip by an actomyosin-based process. mRNA localization created a higher concentration of IST2 protein in the bud compared with that of the mother cell, and this asymmetry was maintained by a septin-mediated membrane diffusion barrier at the mother-bud neck. These results indicate that yeast creates distinct plasma membrane compartments, as has been described in neurons and epithelial cells.
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Cited by
Phillips, G. R., Huang, J. K., Wang, Y., Tanaka, H., Shapiro, L., Zhang, W., Shan, W.-S., Arndt, K., Frank, M., Gordon, R. E., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00450-0 · Cited by 438
The pathobiology of the septin gene family
Hall, P. A., & Russell, S. H. (2004) · The Journal of Pathology · doi:10.1002/path.1654 · Cited by 323
Coupling and coordination in gene expression processes: a systems biology view
Komili, S., & Silver, P. A. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2223 · Cited by 218
Biochemical Computation for Spine Structural Plasticity
Nishiyama, J., & Yasuda, R. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.043 · Cited by 199
Tooley, A. J., Gilden, J., Jacobelli, J., Beemiller, P., Trimble, W. S., Kinoshita, M., & Krummel, M. F. (2009) · Nature Cell Biology · doi:10.1038/ncb1808 · Cited by 189
“The Septin ring around the cytokinetic furrow in yeast functions as a diffusion barrier, maintaining cell fate determinants in the appropriate cell11,12.”
Metadata
- Authors
- Takizawa, P. A., DeRisi, J. L., Wilhelm, J. E., & Vale, R. D.
- Venue
- Science
- Published
- 2000-10-13
- Volume
- 290
- Issue
- 5490
- Pages
- 341-344
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2075787930
- Cited by
- 439
- References
- 0
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Takizawa, P. A., DeRisi, J. L., Wilhelm, J. E., & Vale, R. D. (2000). Plasma Membrane Compartmentalization in Yeast by Messenger RNA Transport and a Septin Diffusion Barrier. Science. https://doi.org/10.1126/science.290.5490.341
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
