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Protection Against Cutaneous Leishmaniasis Resulting from Bites of Uninfected Sand Flies
Abstract
Despite the fact that Leishmania are transmitted exclusively by sand flies, none of the experimental models of leishmaniasis have established infection via sand fly bites. Here we describe a reproducible murine model of Leishmania major infection transmitted by Phlebotomus papatasi . Prior exposure of mice to bites of uninfected sand flies conferred powerful protection against Leishmania major that was associated with a strong delayed-type hypersensitivity response and with interferon-γ production at the site of parasite delivery. These results have important implications for the epidemiology of cutaneous leishmaniasis and suggest a vaccination strategy against this and possibly other vector-borne diseases.
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Citations
Cited by
The immunology of susceptibility and resistance to Leishmania major in mice
Sacks, D., & Noben-Trauth, N. (2002) · Nature Reviews Immunology · doi:10.1038/nri933 · Cited by 1,208
Self-citationIn Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies
Peters, N. C., Egen, J. G., Secundino, N., Debrabant, A., Kimblin, N., Kamhawi, S., Lawyer, P., Fay, M. P., Germain, R. N., & Sacks, D. (2008) · Science · doi:10.1126/science.1159194 · Cited by 834
Self-citationTransmission of Leishmania metacyclic promastigotes by phlebotomine sand flies
Bates, P. A. (2007) · International Journal for Parasitology · doi:10.1016/j.ijpara.2007.04.003 · Cited by 607
Belkaid, Y., Hoffmann, K. F., Mendez, S., Kamhawi, S., Udey, M. C., Wynn, T. A., & Sacks, D. L. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.10.1497 · Cited by 557
Self-citationZhang, L., Peritz, A., & Meggers, E. (2005) · Journal of the American Chemical Society · doi:10.1021/ja042564z · Cited by 308
Metadata
- Authors
- Kamhawi, S., Belkaid, Y., Modi, G., Rowton, E., & Sacks, D.
- Venue
- Science
- Published
- 2000-11-17
- Volume
- 290
- Issue
- 5495
- Pages
- 1351-1354
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2038533031
- Cited by
- 347
- References
- 0
- FWCI
- 11.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kamhawi, S., Belkaid, Y., Modi, G., Rowton, E., & Sacks, D. (2000). Protection Against Cutaneous Leishmaniasis Resulting from Bites of Uninfected Sand Flies. Science. https://doi.org/10.1126/science.290.5495.1351
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
