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Cited by 834

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies

Open access
Peters, Nathan C., Egen, Jackson G., Secundino, Nagila, Debrabant, Alain, Kimblin, Nicola, Kamhawi, Shaden, Lawyer, Phillip, Fay, Michael P., Germain, Ronald N., Sacks, David·2008·Science
DOI 10.1126/science.1159194
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Abstract

Infection with the obligate intracellular protozoan Leishmania is thought to be initiated by direct parasitization of macrophages, but the early events following transmission to the skin by vector sand flies have been difficult to examine directly. Using dynamic intravital microscopy and flow cytometry, we observed a rapid and sustained neutrophilic infiltrate at localized sand fly bite sites. Invading neutrophils efficiently captured Leishmania major ( L.m. ) parasites early after sand fly transmission or needle inoculation, but phagocytosed L.m. remained viable and infected neutrophils efficiently initiated infection. Furthermore, neutrophil depletion reduced, rather than enhanced, the ability of parasites to establish productive infections. Thus, L.m. appears to have evolved to both evade and exploit the innate host response to sand fly bite in order to establish and promote disease.

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Crossref · 10.1126/science.1159194

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Metadata

Authors
Peters, N. C., Egen, J. G., Secundino, N., Debrabant, A., Kimblin, N., Kamhawi, S., Lawyer, P., Fay, M. P., Germain, R. N., & Sacks, D.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2008-08-15
Volume
321
Issue
5891
Pages
970-974
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1159194
OpenAlex
W2122413738
Cited by
834
References
25
FWCI
45.87
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies. https://app.cochat.ai/papers/10.1126/science.1159194
The paper
Peters, N. C., Egen, J. G., Secundino, N., Debrabant, A., Kimblin, N., Kamhawi, S., Lawyer, P., Fay, M. P., Germain, R. N., & Sacks, D. (2008). In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies. Science. https://doi.org/10.1126/science.1159194

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.