The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Regulation of Antigen-Specific CD8 + T Cell Homeostasis by Perforin and Interferon-γ
Abstract
T cell memory depends on factors that regulate expansion and death of these cells after antigenic stimulation. Mice deficient in perforin and interferon-γ (IFN-γ) exhibited increased expansion, altered immunodominance, and decreased death of antigen-specific CD8 + T cells after infection with an attenuated strain of Listeria monocytogenes , which was cleared from these mice. Expansion of CD8 + T cells was controlled by perforin, whereas IFN-γ regulated immunodominance and the death phase. Thus, perforin and IFN-γ regulate distinct elements of CD8 + T cell homeostasis independently of their role as antimicrobial effector molecules.
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Self-citationSelecting and maintaining a diverse T-cell repertoire
Goldrath, A. W., & Bevan, M. J. (1999) · Nature · doi:10.1038/35005508 · Cited by 714
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PD-L2 is a second ligand for PD-1 and inhibits T cell activation
Latchman, Y., Wood, C. R., Chernova, T., Chaudhary, D., Borde, M., Chernova, I., Iwai, Y., Long, A. J., Brown, J. A., Nunes, R., et al. (2001) · Nature Immunology · doi:10.1038/85330 · Cited by 2,955
Joshi, N. S., Cui, W., Chandele, A., Lee, H. K., Urso, D. R., Hagman, J., Gapin, L., & Kaech, S. M. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.010 · Cited by 1,861
Effector and memory T-cell differentiation: implications for vaccine development
Kaech, S. M., Wherry, E. J., & Ahmed, R. (2002) · Nature Reviews Immunology · doi:10.1038/nri778 · Cited by 1,865
Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni1009 · Cited by 1,830
Lymphocyte-Mediated Cytotoxicity
Russell, J. H., & Ley, T. J. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100201.131730 · Cited by 1,122
Metadata
- Authors
- Badovinac, V. P., Tvinnereim, A. R., & Harty, J. T.
- Venue
- Science
- Published
- 2000-11-17
- Volume
- 290
- Issue
- 5495
- Pages
- 1354-1357
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2088801927
- Cited by
- 438
- References
- 33
- FWCI
- 11.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Badovinac, V. P., Tvinnereim, A. R., & Harty, J. T. (2000). Regulation of Antigen-Specific CD8 + T Cell Homeostasis by Perforin and Interferon-γ. Science. https://doi.org/10.1126/science.290.5495.1354
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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