The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Glycolipid Antigen Processing for Presentation by CD1d Molecules
Abstract
The requirement for processing glycolipid antigens in T cell recognition was examined with mouse CD1d-mediated responses to glycosphingolipids (GSLs). Although some disaccharide GSL antigens can be recognized without processing, the responses to three other antigens, including the disaccharide GSL Gal(α1→2)GalCer (Gal, galactose; GalCer, galactosylceramide), required removal of the terminal sugars to permit interaction with the T cell receptor. A lysosomal enzyme, α-galactosidase A, was responsible for the processing of Gal(α1→2)GalCer to generate the antigenic monosaccharide epitope. These data demonstrate a carbohydrate antigen processing system analogous to that used for peptides and an ability of T cells to recognize processed fragments of complex glycolipids.
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Burdin, N., Brossay, L., Koezuka, Y., Smiley, S. T., Grusby, M. J., Gui, M., Taniguchi, M., Hayakawa, K., & Kronenberg, M. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.7.3271 · Cited by 334
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Cited by
Overview of the immune response
Chaplin, D. D. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.12.980 · Cited by 2,235
Lysosomal Glycosphingolipid Recognition by NKT Cells
Zhou, D., Mattner, J., Cantu, C., Schrantz, N., Yin, N., Gao, Y., Sagiv, Y., Hudspeth, K., Wu, Y.-P., Yamashita, T., et al. (2004) · Science · doi:10.1126/science.1103440 · Cited by 956
Apolipoprotein-mediated pathways of lipid antigen presentation
Elzen, P. V. D., Garg, S., León, L., Brigl, M., Leadbetter, E. A., Gumperz, J. E., Dascher, C. C., Cheng, T.-Y., Sacks, F. M., Illarionov, P. A., et al. (2005) · Nature · doi:10.1038/nature04001 · Cited by 380
Cell wall glycosphingolipids ofSphingomonas paucimobilisare CD1d-specific ligands for NKT cells
Sriram, V., Du, W., Gervay-Hague, J., & Brutkiewicz, R. R. (2005) · European Journal of Immunology · doi:10.1002/eji.200526157 · Cited by 309
Oxidative depolymerization of polysaccharides by reactive oxygen/nitrogen species
Duan, J., & Kasper, D. L. (2011) · Glycobiology · doi:10.1093/glycob/cwq171 · Cited by 267
Metadata
- Authors
- Prigozy, T. I., Naidenko, O., Qasba, P., Elewaut, D., Brossay, L., Khurana, A., Natori, T., Koezuka, Y., Kulkarni, A., & Kronenberg, M.
- Venue
- Science
- Published
- 2001-01-26
- Volume
- 291
- Issue
- 5504
- Pages
- 664-667
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1987950952
- Cited by
- 287
- References
- 1
- FWCI
- 5.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Prigozy, T. I., Naidenko, O., Qasba, P., Elewaut, D., Brossay, L., Khurana, A., Natori, T., Koezuka, Y., Kulkarni, A., & Kronenberg, M. (2001). Glycolipid Antigen Processing for Presentation by CD1d Molecules. Science. https://doi.org/10.1126/science.291.5504.664
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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