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Atrial Natriuretic Factor: A Hormone Produced by the Heart
Abstract
Systematic studies on the significance of the secretory-like morphological characteristic of cardiac atrial muscle cells of mammals led to the finding that these cells produce a polypeptide hormone. This hormone, described in 1981 as atrial natriuretic factor (ANF), is diuretic (natriuretic), hypotensive, and has an inhibitory effect on renin and aldosterone secretion. Thus, ANF probably intervenes in the short- and long-term control of water and electrolyte balance and of blood pressure. Phylogenetically, ANF appears early, suggesting different functions for this peptide in accordance with each species' environment. Knowledge of the properties of the hormone should provide insights into the pathophysiology of important clinical entities and lead to the development of new pharmaceutical products.
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Citations
Cited by
Genetic linkage of familial open angle glaucoma to chromosome 1q21–q31
Sheffield, V. C., Stone, E. M., Alward, W. L. M., Drack, A. V., Johnson, A. T., Streb, L. M., & Nichols, B. E. (1993) · Nature Genetics · doi:10.1038/ng0593-47 · Cited by 438
Bandelow, B., Baldwin, D., Abelli, M., Bolea-Alamanac, B., Bourin, M., Chamberlain, S. R., Cinosi, E., Davies, S., Domschke, K., Fineberg, N., et al. (2017) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2016.1190867 · Cited by 347
Nutrient sensing and utilization: getting to the heart of metabolic flexibility
Griffin, T. M., Humphries, K. M., Kinter, M., Lim, H.-Y., & Szweda, L. I. (2016) · Biochimie · doi:10.1016/j.biochi.2015.10.013 · Cited by 36
ABE, H., NAGATOMO, T., KOBAYASHI, H., MIURA, Y., ARAKI, M., KUROIWA, A., & NAKASHIMA, Y. (1997) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.1997.tb05436.x · Cited by 18
Thyrotropin-releasing hormone increases plasma atrial natriuretic peptide levels in human
Sergev, O., Rácz, K., Varga, I., Kiss, R., Fütö, L., Mohari, K., & Gláz, E. (1990) · Journal of Endocrinological Investigation · doi:10.1007/bf03349587 · Cited by 6
Metadata
- Authors
- de Bold, A. J.
- Venue
- Science
- Published
- 1985-11-15
- Volume
- 230
- Issue
- 4727
- Pages
- 767-770
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2121815042
- Cited by
- 981
- References
- 0
- FWCI
- 77.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- de Bold, A. J. (1985). Atrial Natriuretic Factor: A Hormone Produced by the Heart. Science. https://doi.org/10.1126/science.2932797
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
