Cited by 36Cardiovascular Function and Risk FactorsCardiovascular Disease and AdiposityMetabolism, Diabetes, and Cancer

Nutrient sensing and utilization: getting to the heart of metabolic flexibility

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Griffin, Timothy M., Humphries, Kenneth M., Kinter, Michael, Lim, Hui-Ying, Szweda, Luke I.·2016·Biochimie

Abstract

A central feature of obesity-related cardiometabolic diseases is the impaired ability to transition between fatty acid and glucose metabolism. This impairment, referred to as "metabolic inflexibility", occurs in a number of tissues, including the heart. Although the heart normally prefers to metabolize fatty acids over glucose, the inability to upregulate glucose metabolism under energetically demanding conditions contributes to a pathological state involving energy imbalance, impaired contractility, and post-translational protein modifications. This review discusses pathophysiologic processes that contribute to cardiac metabolic inflexibility and speculates on the potential physiologic origins that lead to the current state of cardiometabolic disease in an obesogenic environment.

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Authors
Griffin, T. M., Humphries, K. M., Kinter, M., Lim, H.-Y., & Szweda, L. I.
Affiliations
Oklahoma Medical Research Foundation (US)
Corresponding author
Griffin, Timothy M.
Venue
Biochimie
Publisher
Elsevier BV
Published
2016-05
Volume
124
Pages
74-83
ISSN
  • 0037-9042 (ISSN-L)
  • 0300-9084
OpenAlex
W1752066541
Cited by
36
References
123
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 7 · 2017: 6 · 2016: 4
FWCI
0.97
Type
journal article
Language
en
Open access
Locations
  • Biochimie (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of General Medical Sciences (P20GM103441, P20GM104934, P20GM103636)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R03AR066828)
  • National Institute on Aging (R01AG049058)
  • American Heart Association (14GRNT20510031, 13SDG14680005)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
metabolic flexibility, nutrient sensing, glucose metabolism, fatty acid metabolism, obesity, cardiometabolic disease, heart contractility, post-translational protein modification, energy imbalance
MeSH terms
Animals, Energy Metabolism, Glucose, Heart Diseases, Humans, Myocardial Contraction, Myocardium, Obesity, Protein Processing, Post-Translational

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