The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Immunotherapy of the Nonobese Diabetic Mouse: Treatment with an Antibody to T-Helper Lymphocytes
Abstract
Spontaneous diabetes mellitus was blocked in nonobese diabetic mice by treatment with a monoclonal antibody against the L3T4 determinant present on the surface of T-helper lymphocytes. Sustained treatment with the monoclonal antibody led to cessation of the lymphocytic infiltration associated with the destruction of the insulin-producing β cells. Moreover, the mice remained normoglycemic after the antibody therapy was stopped. These studies indicate that immunotherapy with monoclonal antibodies to the lymphocyte subset may not only halt the progression of diabetes, but may lead to long-term reversal of the disease after therapy has ended.
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Citations
Cites
Eisenbarth (1986) · doi:10.1056/nejm198605223142106 · Cited by 1,659
Cited by
THE NOD MOUSE: A Model of Immune Dysregulation
Anderson, M. S., & Bluestone, J. A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115643 · Cited by 1,113
The Pathogenesis of Insulin-Dependent Diabetes Mellitus
Epstein, F. H., Atkinson, M. A., & Maclaren, N. K. (1994) · New England Journal of Medicine · doi:10.1056/nejm199411243312107 · Cited by 1,078
Following a diabetogenic T cell from genesis through pathogenesis
Katz, J. D., Wang, B., Haskins, K., Benoist, C., & Mathis, D. (1993) · Cell · doi:10.1016/0092-8674(93)90730-e · Cited by 696
T Helper Cell Subsets in Insulin-Dependent Diabetes
Katz, J. D., Benoist, C., & Mathis, D. (1995) · Science · doi:10.1126/science.7761837 · Cited by 593
Autoimmune Diseases: The Failure of Self Tolerance
Sinha, A. A., Lopez, M. T., & McDevitt, H. O. (1990) · Science · doi:10.1126/science.1972595 · Cited by 493
Metadata
- Authors
- Shizuru, J. A., Taylor-Edwards, C., Banks, B. A., Gregory, A. K., & Fathman, C. G.
- Venue
- Science
- Published
- 1988-04-29
- Volume
- 240
- Issue
- 4852
- Pages
- 659-662
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2089037219
- Cited by
- 345
- References
- 1
- FWCI
- 15.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shizuru, J. A., Taylor-Edwards, C., Banks, B. A., Gregory, A. K., & Fathman, C. G. (1988). Immunotherapy of the Nonobese Diabetic Mouse: Treatment with an Antibody to T-Helper Lymphocytes. Science. https://doi.org/10.1126/science.2966437
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
