The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function
Abstract
The study of human hematopoietic cells and the human immune system is hampered by the lack of a suitable experimental model. Experimental data are presented showing that human fetal liver hematopoietic cells, human fetal thymus, and human fetal lymph node support the differentiation of mature human T cells and B cells after engraftment into mice with genetically determined severe combined immunodeficiency. The resultant SCID-hu mice are found to have a transient wave of human CD4+ and CD8+ T cells and human IgG (immunoglobulin G) in the peripheral circulation. The functional status of the human immune system within this mouse model is not yet known.
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Cited by
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Peled, A., Petit, I., Kollet, O., Magid, M., Ponomaryov, T., Byk, T., Nagler, A., Ben-Hur, H., Many, A., Shultz, L., et al. (1999) · Science · doi:10.1126/science.283.5403.845 · Cited by 1,644
Self-citationSimsek, T., Kocabas, F., Zheng, J., DeBerardinis, R. J., Mahmoud, A. I., Olson, E. N., Schneider, J. W., Zhang, C. C., & Sadek, H. A. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.07.011 · Cited by 1,101
Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age
Pang, W. W., Price, E. A., Sahoo, D., Beerman, I., Maloney, W. J., Rossi, D. J., Schrier, S. L., & Weissman, I. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116110108 · Cited by 991
Self-citationHematopoiesis: a human perspective
Doulatov, S., Notta, F., Laurenti, E., & Dick, J. E. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.01.006 · Cited by 895
Leukaemia stem cells and the evolution of cancer-stem-cell research
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Metadata
- Authors
- McCune, J., Namikawa, R., Kaneshima, H., Shultz, L., Lieberman, M., & Weissman, I.
- Venue
- Science
- Published
- 1988-09-23
- Volume
- 241
- Issue
- 4873
- Pages
- 1632-1639
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2010519150
- Cited by
- 1,406
- References
- 1
- FWCI
- 21.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- McCune, J., Namikawa, R., Kaneshima, H., Shultz, L., Lieberman, M., & Weissman, I. (1988). The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science. https://doi.org/10.1126/science.241.4873.1632
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
