The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Trans -Acting Transcriptional Regulation of Human T-Cell Leukemia Virus Type III Long Terminal Repeat
Abstract
Human T-cell leukemia virus type III (HTLV-III) was recently identified as the probable etiologic agent of the acquired immune deficiency syndrome (AIDS). Here it is shown that, in human T-cell lines infected with HTLV-III, gene expression directed by the long terminal repeat sequence of this virus is stimulated by more than two orders of magnitude compared to matched uninfected cells. The rate of transcription of the HTLV-III long terminal repeat is more than 1000 times that of the SV40 early promoter in one infected cell line. Thus, HTLV-III, like HTLV-I, HTLV-II, and the bovine leukemia virus, is characterized by trans -activation of transcription in infected cells. The efficiency of trans -activation in the case of HTLV-III may account, at least in part, for the virulent nature of HTLV-III infection.
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Cites
Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.
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Self-citationPopovic, M., Sarngadharan, M. G., Read, E., & Gallo, R. C. (1984) · Science · doi:10.1126/science.6200935 · Cited by 3,535
Self-citationYoshida, M., Miyoshi, I., & Hinuma, Y. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.6.2031 · Cited by 2,169
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Cited by
An inducible transcription factor activates expression of human immunodeficiency virus in T cells
Nabel, G., & Baltimore, D. (1987) · Nature · doi:10.1038/326711a0 · Cited by 2,041
Molecular Targets for AIDS Therapy
Mitsuya, H., Yarchoan, R., & Broder, S. (1990) · Science · doi:10.1126/science.1699273 · Cited by 732
A second post-transcriptional trans-activator gene required for HTLV-III replication
Sodroski, J., Goh, W. C., Rosen, C., Dayton, A., Terwilliger, E., & Haseltine, W. (1986) · Nature · doi:10.1038/321412a0 · Cited by 631
Self-citationThe trans-activator gene of the human T cell lymphotropic virus type III is required for replication
Dayton, A. (1986) · Cell · doi:10.1016/0092-8674(86)90017-6 · Cited by 621
Major Glycoprotein Antigens That Induce Antibodies in AIDS Patients Are Encoded by HTLV-III
Allan, J. S., Coligan, J. E., Barin, F., McLane, M. F., Sodroski, J. G., Rosen, C. A., Haseltine, W. A., Lee, T. H., & Essex, M. (1985) · Science · doi:10.1126/science.2986290 · Cited by 572
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Metadata
- Authors
- Sodroski, J., Rosen, C., Wong-Staal, F., Salahuddin, S. Z., Popovic, M., Arya, S., Gallo, R. C., & Haseltine, W. A.
- Venue
- Science
- Published
- 1985-01-11
- Volume
- 227
- Issue
- 4683
- Pages
- 171-173
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2013357966
- Cited by
- 493
- References
- 30
- FWCI
- 25.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sodroski, J., Rosen, C., Wong-Staal, F., Salahuddin, S. Z., Popovic, M., Arya, S., Gallo, R. C., & Haseltine, W. A. (1985). Trans -Acting Transcriptional Regulation of Human T-Cell Leukemia Virus Type III Long Terminal Repeat. Science. https://doi.org/10.1126/science.2981427
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
