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Cited by 1,196

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

A New Subtype of Human T-Cell Leukemia Virus (HTLV-II) Associated with a T-Cell Variant of Hairy Cell Leukemia

Kalyanaraman, V. S., Sarngadharan, M. G., Robert-Guroff, Marjorie, Miyoshi, Isao, Blayney, Douglas, Golde, David, Gallo, Robert C.·1982·Science

Abstract

Human T-cell leukemia virus (HTLV) is a human type-C RNA tumor virus (retrovirus) previously identified in and isolated from several patients with T-cell leukemias or lymphomas. The known virus isolates from the United States and Japan are closely related and are found in adults with an acute malignancy of mature T cells. A related retrovirus has been found in a patient (Mo) with a somewhat different disease (a T-cell variant of relatively benign hairy cell leukemia). Serum from Mo contains antibodies to the major internal core protein (p24) of HTLV. A T-cell line established from the spleen of Mo expresses HTLV antigens. However, HTLV from Mo is significantly different from all previous HTLV isolates in immunological cross-reactivity tests of p24. The usual prototype HTLV isolate is represented as HTLV-I, and the HTLV from Mo is represented as HTLV-II. Individual members of each subgroup may then be identified by subscript initials of the patient [for example, HTLV-I (CR) , HTLV-I (MB) , and HTLV-II (Mo) ].

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Metadata

Authors
Kalyanaraman, V. S., Sarngadharan, M. G., Robert-Guroff, M., Miyoshi, I., Blayney, D., Golde, D., & Gallo, R. C.
Venue
Science
Published
1982-11-05
Volume
218
Issue
4572
Pages
571-573
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1979637191
Cited by
1,196
References
2
FWCI
37.18
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: A New Subtype of Human T-Cell Leukemia Virus (HTLV-II) Associated with a T-Cell Variant of Hairy Cell Leukemia. https://app.cochat.ai/papers/10.1126/science.6981847
The paper
Kalyanaraman, V. S., Sarngadharan, M. G., Robert-Guroff, M., Miyoshi, I., Blayney, D., Golde, D., & Gallo, R. C. (1982). A New Subtype of Human T-Cell Leukemia Virus (HTLV-II) Associated with a T-Cell Variant of Hairy Cell Leukemia. Science. https://doi.org/10.1126/science.6981847

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.