The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cloning of Large Segments of Exogenous DNA into Yeast by Means of Artificial Chromosome Vectors
Abstract
Fragments of exogenous DNA that range in size up to several hundred kilobase pairs have been cloned into yeast by ligating them to vector sequences that allow their propagation as linear artificial chromosomes. Individual clones of yeast and human DNA that have been analyzed by pulsed-field gel electrophoresis appear to represent faithful replicas of the source DNA. The efficiency with which clones can be generated is high enough to allow the construction of comprehensive libraries from the genomes of higher organisms. By offering a tenfold increase in the size of the DNA molecules that can be cloned into a microbial host, this system addresses a major gap in existing experimental methods for analyzing complex DNA sources.
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Citations
Cites
Somatic generation of antibody diversity
Tonegawa, S. (1983) · Nature · doi:10.1038/302575a0 · Cited by 4,005
Cited by
Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216
Self-citationA highly conserved repetitive DNA sequence,(TTAGGG) n, present at the telomeres of human chromosomes
Moyzis, R. K., Buckingham, J. M., Cram, L. S., Dani, M., Deaven, L. L., Jones, M. D., Meyne, J., Ratliff, R. L., & Wu, J. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.18.6622 · Cited by 1,820
Complete Chemical Synthesis, Assembly, and Cloning of a Mycoplasma genitalium Genome
Gibson, D. G., Benders, G. A., Andrews-Pfannkoch, C., Denisova, E. A., Baden-Tillson, H., Zaveri, J., Stockwell, T. B., Brownley, A., Thomas, D. W., Algire, M. A., et al. (2008) · Science · doi:10.1126/science.1151721 · Cited by 1,243
Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg
Vidal, S. M., Malo, D., Vogan, K., Skamene, E., & Gros, P. (1993) · Cell · doi:10.1016/0092-8674(93)90135-d · Cited by 1,104
Yang, X. W., Model, P., & Heintz, N. (1997) · Nature Biotechnology · doi:10.1038/nbt0997-859 · Cited by 544
Metadata
- Authors
- Burke, D. T., Carle, G. F., & Olson, M. V.
- Venue
- Science
- Published
- 1987-05-15
- Volume
- 236
- Issue
- 4803
- Pages
- 806-812
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2021608281
- Cited by
- 1,501
- References
- 1
- FWCI
- 29.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Burke, D. T., Carle, G. F., & Olson, M. V. (1987). Cloning of Large Segments of Exogenous DNA into Yeast by Means of Artificial Chromosome Vectors. Science. https://doi.org/10.1126/science.3033825
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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