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Rheumatoid Factor Secretion from Human Leu-1 + B Cells
Abstract
A human B cell subpopulation identifiable by the expression of the cell surface antigen Leu-1 (CD5) is responsible for most of the immunoglobulin M rheumatoid factor secreted in vitro after the cells are stimulated with Staphylococcus aureus . The ability of B cells bearing the Leu-1 marker (Leu-1 + ) to secrete rheumatoid factor is present early in development and extends to adulthood, since Leu-1 + B cells from cord blood and from peripheral blood lymphocytes of both normal adults and patients with certain autoimmune conditions secrete rheumatoid factor in comparable amounts. The neonatal enrichment of Leu-1 + B cells, the presence of Leu-1 + B cells in increased frequencies in patients with autoimmune disease, and the involvement of Leu-1 + B cells in autoantibody secretion suggest both developmental and functional homologies between this human B cell subpopulation and the murine Ly-1 B cell subpopulation.
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Cited by
The double life of a B-1 cell: self-reactivity selects for protective effector functions
Baumgarth, N. (2011) · Nature Reviews Immunology · doi:10.1038/nri2901 · Cited by 969
Mantle Cell Lymphoma A Proposal for Unification of Morphologic, Immunologic, and Molecular Data
Banks, P. M., Chan, J., Cleary, M. L., Delsol, G., De Wolf-Peeters, C., Gatter, K., Grogan, T. M., Harris, N. L., Isaacson, P. G., Jaffe, E. S., et al. (1992) · The American Journal of Surgical Pathology · doi:10.1097/00000478-199207000-00001 · Cited by 508
Immune responses that adapt the intestinal mucosa to commensal intestinal bacteria
Macpherson, A. J., Geuking, M. B., & McCoy, K. D. (2005) · Immunology · doi:10.1111/j.1365-2567.2005.02159.x · Cited by 283
Shoenfeld, Y., & Isenberg, D. A. (1989) · Immunology Today · doi:10.1016/0167-5699(89)90245-4 · Cited by 288
Hardy, R. R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.5.2749 · Cited by 249
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Metadata
- Authors
- Hardy, R. R., Hayakawa, K., Shimizu, M., Yamasaki, K., & Kishimoto, T.
- Venue
- Science
- Published
- 1987-04-03
- Volume
- 236
- Issue
- 4797
- Pages
- 81-83
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2021916493
- Cited by
- 440
- References
- 0
- FWCI
- 16.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hardy, R. R., Hayakawa, K., Shimizu, M., Yamasaki, K., & Kishimoto, T. (1987). Rheumatoid Factor Secretion from Human Leu-1 + B Cells. Science. https://doi.org/10.1126/science.3105057
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