The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The Primary Structure and Heterogeneity of Tau Protein from Mouse Brain
Abstract
Tau protein is a family of microtubule binding proteins, heterogeneous in molecular weight, that are induced during neurite outgrowth and are found prominently in neurofibrillary tangles in Alzheimer's disease. The predicted amino acid sequences of two forms of tau protein from mouse brain were determined from complementary DNA clones. These forms are identical in their amino-terminal sequences but differ in their carboxyl-terminal domains. Both proteins contain repeated sequences that may be tubulin binding sites. The sequence suggests that tau is an elongated molecule with no extensive α-helical or β-sheet domains. These complementary DNAs should enable the study of various functional domains of tau and the study of tau expression in normal and pathological states.
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Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741
Cleveland, D. W., Hwo, S.-Y., & Kirschner, M. W. (1977) · Journal of Molecular Biology · doi:10.1016/0022-2836(77)90213-3 · Cited by 915
Self-citationPhosphorylation affects the ability of tau protein to promote microtubule assembly.
Lindwall, G., & Cole, R. D. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42989-9 · Cited by 901
Research works printed but not linked: 29
- Bio-Rad Laboratories Bulletin 1205: (1985).
- CLEVELAND, D.W., MOLECULAR-BIOLOGY AND GENETICS OF TUBULIN, ANNUAL REVIEW OF BIOCHEMISTRY 54: 331 (1985). · DOI · Paper page
- CLEVELAND, D.W., PHYSICAL AND CHEMICAL PROPERTIES OF PURIFIED TAU FACTOR AND ROLE OF TAU IN MICROTUBULE ASSEMBLY, JOURNAL OF MOLECULAR BIOLOGY 116: 227 (1977). · DOI · Paper page
- CONNOLLY, J.A., THE DISTRIBUTION OF TAU AND HMW MICROTUBULE-ASSOCIATED PROTEINS IN DIFFERENT CELL-TYPES, EXPERIMENTAL CELL RESEARCH 127: 341 (1980). · DOI
- CONNOLLY, J.A., INTRACELLULAR-LOCALIZATION OF HIGH MOLECULAR-WEIGHT MICROTUBULE ACCESSORY PROTEIN BY INDIRECT IMMUNOFLUORESCENCE, JOURNAL OF CELL BIOLOGY 76: 781 (1978). · DOI
- CONNOLLY, J.A., IMMUNOFLUORESCENT STAINING OF CYTOPLASMIC AND SPINDLE MICROTUBULES IN MOUSE FIBROBLASTS WITH ANTIBODY TO TAU-PROTEIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 74: 2437 (1977).
- DRUBIN, D, ASSOCIATION OF TAU-PROTEIN WITH MICROTUBULES IN LIVING CELLS, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 466: 257 (1986). · DOI
- DRUBIN, D.G., STUDIES ON THE EXPRESSION OF THE MICROTUBULE-ASSOCIATED PROTEIN, TAU, DURING MOUSE-BRAIN DEVELOPMENT, WITH NEWLY ISOLATED COMPLEMENTARY-DNA PROBES, JOURNAL OF CELL BIOLOGY 98: 1090 (1984). · DOI
- DRUBIN, D.G., NERVE GROWTH-FACTOR INDUCED NEURITE OUTGROWTH IN PC12 CELLS INVOLVES THE COORDINATE INDUCTION OF MICROTUBULE ASSEMBLY AND ASSEMBLY-PROMOTING FACTORS, JOURNAL OF CELL BIOLOGY 101: 1799 (1985). · DOI
- DRUBIN, D.G., TAU-PROTEIN FUNCTION IN LIVING CELLS, JOURNAL OF CELL BIOLOGY 103: 2739 (1986). · DOI · Paper page
- FELLOUS, A, MICROTUBULE ASSEMBLY INVITRO - PURIFICATION OF ASSEMBLY-PROMOTING FACTORS, EUROPEAN JOURNAL OF BIOCHEMISTRY 78: 167 (1977). · DOI
- GINZBURG, I, MODULATION OF MESSENGER-RNA FOR MICROTUBULE-ASSOCIATED PROTEINS DURING BRAIN-DEVELOPMENT, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79: 4892 (1982).
- GRUNDKEIQBAL, I, MICROTUBULE-ASSOCIATED PROTEIN-TAU - A COMPONENT OF ALZHEIMER PAIRED HELICAL FILAMENTS, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 6084 (1986). · DOI
- 10.1016/0378-1119(83)90230-5 · DOI
- HERZOG, W, FRACTIONATION OF BRAIN MICROTUBULE-ASSOCIATED PROTEINS - ISOLATION OF 2 DIFFERENT PROTEINS WHICH STIMULATE TUBULIN POLYMERIZATION INVITRO, EUROPEAN JOURNAL OF BIOCHEMISTRY 92: 1 (1978). · DOI
- 10.1038/321605a0 · DOI
- IHARA, Y, JOURNAL OF NEUROCHEMISTRY 48: S14 (1987).
- KOSIK, K.S., MICROTUBULE-ASSOCIATED PROTEIN TAU (TAU) IS A MAJOR ANTIGENIC COMPONENT OF PAIRED HELICAL FILAMENTS IN ALZHEIMER-DISEASE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 4044 (1986).
- LEWIS, S.A., FREE INTERMINGLING OF MAMMALIAN BETA-TUBULIN ISOTYPES AMONG FUNCTIONALLY DISTINCT MICROTUBULES, CELL 49: 539 (1987). · DOI
- LEWIS, S.A., BRAIN-SPECIFIC EXPRESSION OF MAP2 DETECTED USING A CLONED CDNA PROBE, JOURNAL OF CELL BIOLOGY 102: 2098 (1986). · DOI
- MOSTOV, K.E., THE RECEPTOR FOR TRANS-EPITHELIAL TRANSPORT OF IGA AND IGM CONTAINS MULTIPLE IMMUNOGLOBULIN-LIKE DOMAINS, NATURE 308: 37 (1984). · DOI
- MOUNT, S.M., A CATALOG OF SPLICE JUNCTION SEQUENCES, NUCLEIC ACIDS RESEARCH 10: 459 (1982). · DOI
- NUKINA, N, ONE OF THE ANTIGENIC DETERMINANTS OF PAIRED HELICAL FILAMENTS IS RELATED TO TAU PROTEIN, JOURNAL OF BIOCHEMISTRY 99: 1541 (1986). · DOI
- OLMSTED, J.B., MICROTUBULE-ASSOCIATED PROTEINS, ANNUAL REVIEW OF CELL BIOLOGY 2: 421 (1986). · DOI
- PFEFFER, S.R., IDENTIFICATION OF 3 COATED VESICLE COMPONENTS AS ALPHA-TUBULIN AND BETA-TUBULIN LINKED TO A PHOSPHORYLATED 50,000-DALTON POLYPEPTIDE, JOURNAL OF CELL BIOLOGY 97: 40 (1983). · DOI
- 10.1073/pnas.74.12.5463 · DOI · Paper page
- WEINGARTEN, M.D., PROTEIN FACTOR ESSENTIAL FOR MICROTUBULE ASSEMBLY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 72: 1858 (1975).
- WOOD, J.G., NEUROFIBRILLARY TANGLES OF ALZHEIMER-DISEASE SHARE ANTIGENIC DETERMINANTS WITH THE AXONAL MICROTUBULE-ASSOCIATED PROTEIN TAU (TAU), PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 4040 (1986).
- YAFFE, D, HIGHLY CONSERVED SEQUENCES IN THE 3' UNTRANSLATED REGION OF MESSENGER-RNAS CODING FOR HOMOLOGOUS PROTEINS IN DISTANTLY RELATED SPECIES, NUCLEIC ACIDS RESEARCH 13: 3723 (1985). · DOI
Cited by
Goedert, M., Spillantini, M. G., Jakes, R., Rutherford, D., & Crowther, R. A. (1989) · Neuron · doi:10.1016/0896-6273(89)90210-9 · Cited by 2,492
Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models
Ittner, L. M., Ke, Y. D., Delerue, F., Bi, M., Gladbach, A., van Eersel, J., Wölfing, H., Chieng, B. C., Christie, M. J., Napier, I. A., et al. (2010) · Cell · doi:10.1016/j.cell.2010.06.036 · Cited by 1,821
Tau protein liquid–liquid phase separation can initiate tau aggregation
Wegmann, S., Eftekharzadeh, B., Tepper, K., Zoltowska, K. M., Bennett, R. E., Dujardin, S., Laskowski, P. R., MacKenzie, D., Kamath, T., Commins, C., et al. (2018) · The EMBO Journal · doi:10.15252/embj.201798049 · Cited by 1,102
Goedert, M., Wischik, C. M., Crowther, R. A., Walker, J. E., & Klug, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.11.4051 · Cited by 1,134
Goedert, M., Spillantini, M. G., Potier, M. C., Ulrich, J., & Crowther, R. A. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03390.x · Cited by 1,037
Metadata
- Authors
- Lee, G., Cowan, N., & Kirschner, M.
- Venue
- Science
- Published
- 1988-01-15
- Volume
- 239
- Issue
- 4837
- Pages
- 285-288
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2026771024
- Cited by
- 678
- References
- 3
- FWCI
- 39.44
- Type
- journal article
- Language
- en
- Open access
- closed
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