Cited by 903Alzheimer's disease research and treatmentsMicrotubule and mitosis dynamicsCancer Treatment and Pharmacology

Phosphorylation affects the ability of tau protein to promote microtubule assembly.

Open access
Lindwall, G, Cole, R D·1984·Journal of Biological Chemistry

Abstract

Tau is a family of closely related proteins known for its ability to copolymerize with tubulin, inducing the formation of microtubules. When tau was stripped of phosphate by treatment with alkaline phosphatase it underwent a pronounced change in electrophoretic mobility, probably reflecting a conformational change. The dephosphorylated tau promoted significantly more rapid and more extensive polymerization of microtubules though there was no obvious difference in the microtubules formed. Partially purified microtubule protein contains a kinase that can rephosphorylate tau.

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Crossref · 10.1016/s0021-9258(17)42989-9

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33 of 33 references verified0 citation errors · 0 not checkable

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Authors
Lindwall, G., & Cole, R. D.
Affiliations
University of California, Berkeley (US)
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1984-04
Volume
259
Issue
8
Pages
5301-5305
ISSN
0021-9258 (ISSN-L)
OpenAlex
W1481130297
Cited by
901
References
33
Citations by year
2026: 8 · 2025: 27 · 2024: 19 · 2023: 28 · 2022: 38 · 2021: 41 · 2020: 40 · 2019: 39 · 2018: 25 · 2017: 25 · 2016: 31 · 2015: 18 · 2014: 18 · 2013: 23 · 2012: 26
FWCI
13.00
Type
journal article
Language
en
Open access
Locations
  • Journal of Biological Chemistry (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
Keywords
tau protein, phosphorylation, microtubule assembly, dephosphorylation, alkaline phosphatase, protein conformational change, electrophoretic mobility
MeSH terms
Alkaline Phosphatase, Animals, Brain, Cattle, Kinetics, Microscopy, Electron, Microtubules, Nerve Tissue Proteins, Phosphorylation, Proteins, Tubulin, tau Proteins, Macromolecular Substances

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