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Interferon-γ: the Major Mediator of Resistance Against Toxoplasma gondii
Abstract
Mice were injected with a monoclonal antibody to interferon-γ to examine the importance of endogenous production of this lymphokine in resistance against infection with the sporozoan parasite Toxoplasma gondii . Mice with intraperitoneal infections of T. gondii that received no antibody survived and developed chronic T. gondii infection, whereas the infected mice that received the monoclonal antibody died of toxoplasmosis. The activation of macrophages, which kill T. gondii in vivo, was inhibited by administration of the monoclonal antibody, but the production of antibodies to T. gondii was not suppressed. The fact that an antibody to interferon-γ can eliminate resistance to acute Toxoplasma infection in mice suggests that this lymphokine is an important mediator of host resistance to this parasite.
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Cited by
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Nayak, D., Roth, T. L., & McGavern, D. B. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120240 · Cited by 1,154
Gazzinelli, R. T., Hieny, S., Wynn, T. A., Wolf, S., & Sher, A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.13.6115 · Cited by 835
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Metadata
- Authors
- Suzuki, Y., Orellana, M. A., Schreiber, R. D., & Remington, J. S.
- Venue
- Science
- Published
- 1988-04-22
- Volume
- 240
- Issue
- 4851
- Pages
- 516-518
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1998047654
- Cited by
- 1,173
- References
- 0
- FWCI
- 17.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- Suzuki, Y., Orellana, M. A., Schreiber, R. D., & Remington, J. S. (1988). Interferon-γ: the Major Mediator of Resistance Against Toxoplasma gondii. Science. https://doi.org/10.1126/science.3128869
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
