CNS Infection and Immune Privilege

Forrester, John V.; McMenamin, Paul G.; Dando, Samantha J.

doi:10.1038/s41583-018-0070-8

Cited by 313Neuroinflammation and Neurodegeneration MechanismsInfectious Diseases and TuberculosisBarrier Structure and Function Studies

CNS Infection and Immune Privilege

Forrester, John V., McMenamin, Paul G., Dando, Samantha J.·2018·Nature Reviews Neuroscience

DOI 10.1038/s41583-018-0070-8

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Abstract

Classically, the CNS is described as displaying immune privilege, as it shows attenuated responses to challenge by alloantigen. However, the CNS does show local inflammation in response to infection. Although pathogen access to the brain parenchyma and retina is generally restricted by physiological and immunological barriers, certain pathogens may breach these barriers. In the CNS, such pathogens may either cause devastating inflammation or benefit from immune privilege in the CNS, where they are largely protected from the peripheral immune system. Thus, some pathogens can persist as latent infections and later be reactivated. We review the consequences of immune privilege in the context of CNS infections and ask whether immune privilege may provide protection for certain pathogens and promote their latency.

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The first line of protection comes from endothelial, epithelial, and glial barriers.
“The first line of protection comes from endothelial, epithelial, and glial barriers (reviewed by Forrester et al. 2018 [58]).”
From Risk mitigation of immunogenicity: a key to personalized retinal gene therapy (2021) · cites this paper as [58]

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Authors: Forrester, J. V., McMenamin, P. G., & Dando, S. J.
Affiliations: Lions Eye Institute (AU)
Monash University (AU)
Corresponding author: Forrester, John V.
ORCID: Forrester, John V.
McMenamin, Paul G.
Dando, Samantha J.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2018-10-11
Volume: 19
Issue: 11
Pages: 655-671
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/s41583-018-0070-8
OpenAlex: W2895986434
Cited by: 313
References: 253
Citations by year: 2026: 24 · 2025: 39 · 2024: 55 · 2023: 36 · 2022: 41 · 2021: 64 · 2020: 35 · 2019: 17 · 2018: 2
FWCI: 2.79
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
UWA Profiles and Research Repository (UWA) (submittedVersion)
Funders: University of Aberdeen
Medical Research Council
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords: central nervous system infection, immune privilege, neuroinflammation, blood-brain barrier, blood-retinal barrier, viral latency, viral reactivation, alloantigen tolerance
MeSH terms: Immune Privilege, Animals, Brain, Central Nervous System, Central Nervous System Infections, Encephalitis, Humans, Microglia

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