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Effect of Vanadate on Elevated Blood Glucose and Depressed Cardiac Performance of Diabetic Rats
Abstract
The trace element vanadium has an unclear biological function. Vanadate, an oxidized form of vanadium, appears to have an insulin-like action. The effect of vanadate on blood glucose and cardiac performance was assessed in female Wistar rats 6 weeks after they were made diabetic with streptozotocin. When vanadate was administered for a 4-week period to the diabetic rats, their blood glucose was not significantly different from that of nondiabetic controls despite a low serum insulin. In contrast, blood glucose was increased about threefold in the diabetic rats that were not treated with vanadate; these rats also had low insulin levels. Cardiac performance was depressed in the untreated diabetic animals, but the cardiac performance of the vanadate-treated diabetic animals was not significantly different from that of nondiabetic controls. Thus vanadate controlled the high blood glucose and prevented the decline in cardiac performance due to diabetes.
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Cited by
Vanadium compounds in medicine
Pessoa, J. C., Etcheverry, S., & Gambino, D. (2015) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2014.12.002 · Cited by 561
Posner, B. I., Faure, R., Burgess, J. W., Bevan, A. P., Lachance, D., Zhang-Sun, G., Fantus, I. G., Ng, J. B., Hall, D. A., & Lum, B. S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41818-7 · Cited by 532
Heffetz, D., Bushkin, I., Dror, R., & Zick, Y. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39885-0 · Cited by 429
Genet, S., Kale, R. K., & Baquer, N. Z. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1016103131408 · Cited by 258
Stapleton, S. R. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000669 · Cited by 249
Metadata
- Authors
- Heyliger, C. E., Tahiliani, A. G., & McNeill, J. H.
- Venue
- Science
- Published
- 1985-03-22
- Volume
- 227
- Issue
- 4693
- Pages
- 1474-1477
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2039707682
- Cited by
- 711
- References
- 0
- FWCI
- 15.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Heyliger, C. E., Tahiliani, A. G., & McNeill, J. H. (1985). Effect of Vanadate on Elevated Blood Glucose and Depressed Cardiac Performance of Diabetic Rats. Science. https://doi.org/10.1126/science.3156405
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