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Growth Cone Guidance in Insects: Fasciclin II Is a Member of the Immunoglobulin Superfamily
Abstract
The cellular cues that guide neuronal growth cones toward their targets are highly conserved in such diverse organisms as insects and vertebrates. Evidence presented here suggests that the molecular mechanisms underlying these events may be equally conserved. This article describes the structure and function of fasciclin II, a glycoprotein expressed on a subset of fasciculating axons in the grasshopper embryo. Antibody perturbation experiments suggest that fasciclin II functions in mediating one form of neuronal recognition: selective fasciculation. Fasciclin II is a member of the immunoglobulin gene superfamily and is homologous in structure and function to the neural cell adhesion molecule N-CAM and to several other vertebrate cell adhesion molecules.
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Cited by
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Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477
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Pinker, S., & Bloom, P. (1990) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00081061 · Cited by 1,330
The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules
Kolodkin, A. L., Matthes, D. J., & Goodman, C. S. (1993) · Cell · doi:10.1016/0092-8674(93)90625-z · Cited by 963
Self-citationExtracellular Matrix Molecules And Their Receptors: Functions In Neural Development
Reichardt, L. F., & Tomaselli, K. J. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.002531 · Cited by 750
Legouis, R., Hardelin, J.-P., Levilliers, J., Claverie, J.-M., Compain, S., Wunderle, V., Millasseau, P., Le Paslier, D., Cohen, D., & Caterina, D. (1991) · Cell · doi:10.1016/0092-8674(91)90193-3 · Cited by 678
Metadata
- Authors
- Harrelson, A. L., & Goodman, C. S.
- Venue
- Science
- Published
- 1988-11-04
- Volume
- 242
- Issue
- 4879
- Pages
- 700-708
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1982326391
- Cited by
- 423
- References
- 0
- FWCI
- 22.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- Harrelson, A. L., & Goodman, C. S. (1988). Growth Cone Guidance in Insects: Fasciclin II Is a Member of the Immunoglobulin Superfamily. Science. https://doi.org/10.1126/science.3187519
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