Extracellular Matrix Molecules And Their Receptors: Functions In Neural Development
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The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
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Integrins are heterodimeric transmembrane receptors consisting of an α and β subunits that integrate extracellular matrix adhesion with the actin cytoskeleton.
“Integrins are heterodimeric transmembrane receptors that consist of an α and β subunits that integrate extracellular matrix (ECM) adhesion with the actin cytoskeleton (Reichardt and Tomaselli 1991)”
From The Serine/Threonine Kinase <scp>NDR2</scp> Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus (2025) · cites this paper as Reichardt and Tomaselli 1991
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Two contrary functions of tenascin: Dissection of the active sites by recombinant tenascin fragments
Spring, J., Beck, K., & Chiquet-Ehrismann, R. (1989) · Cell · doi:10.1016/0092-8674(89)90294-8 · Cited by 413 · see citing works
Domains of laminin with growth-factor activity
Panayotou, G., End, P., Aumailley, M., Timpl, R., & Engel, J. (1989) · Cell · doi:10.1016/0092-8674(89)90987-2 · Cited by 341 · see citing works
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Extracellular Matrix: Functions in the Nervous System
Barros, C. S., Franco, S. J., & Muller, U. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005108 · Cited by 506 · see citing works
Venstrom, K. A., & Reichardt, L. F. (1993) · The FASEB Journal · doi:10.1096/fasebj.7.11.8370483 · Cited by 269 · see citing works
Self-citationKireeva, M. L., Lam, S. C.-T., & Lau, L. F. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.5.3090 · Cited by 203 · see citing works
Integrins as receptor targets for neurological disorders
Wu, X., & Reddy, D. S. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.12.008 · Cited by 175 · see citing works
“The β1-integrin receptors were first identified as mediators of neurite outgrowth on ECM components (Reichardt & Tomaselli, 1991).”
Struyk, A., Canoll, P., Wolfgang, M., Rosen, C., D'Eustachio, P., & Salzer, J. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-03-02141.1995 · Cited by 142 · see citing works
Ward, N. L., & Lamanna, J. C. (2004) · Neurological Research · doi:10.1179/016164104x3798 · Cited by 122 · see citing works
Gil, O. D., Zanazzi, G., Struyk, A. F., & Salzer, J. L. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-22-09312.1998 · Cited by 111 · see citing works
Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex
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Perineuronal nets of extracellular matrix around parvalbumin‐containing neurons of the hippocampus
Celio, M. R. (1993) · Hippocampus · doi:10.1002/hipo.1993.4500030709 · Cited by 89 · see citing works
Kallmann’s syndrome, a neuronal migration defect
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del Ángel, M., Tsutiya, A., Hayani, H., Madencioglu, D., Kul, E., Caliskan, G., Demiray, Y. E., Dityatev, A., & Stork, O. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70094 · Cited by 1 · see citing works
“…transmembrane receptors that consist of an α and β subunits that integrate extracellular matrix (ECM) adhesion with the actin cytoskeleton (Reichardt and Tomaselli 1991) through adapter proteins such as Talin and Filamin, and intracellular signaling pathways involving various Rho GTPases,…”
- Authors
- Reichardt, L. F., & Tomaselli, K. J.
- Affiliations
- University of California, San Francisco (US)
- ORCID
- Reichardt, L F
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 1991-03
- Volume
- 14
- Issue
- 1
- Pages
- 531-570
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- PMC
- PMC2758225
- OpenAlex
- W2138559670
- Cited by
- 750
- References
- 2
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 6 · 2020: 6 · 2019: 5 · 2018: 11 · 2017: 9 · 2016: 4 · 2015: 6 · 2014: 13 · 2013: 7 · 2012: 17
- FWCI
- 26.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS019090)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- extracellular matrix, ECM receptors, neural development, brain development, default mode network, parietal cortex, prefrontal cortex, temporal cortex
- MeSH terms
- Animals, Humans, Nerve Tissue Proteins, Nervous System, Receptors, Cell Surface
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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