The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Fish Oil Prevents Insulin Resistance Induced by High-Fat Feeding in Rats
Abstract
Non-insulin-dependent diabetes mellitus is an increasingly prevalent disease in Western and developing societies. A major metabolic abnormality of non-insulin-dependent diabetes is impaired insulin action (insulin resistance). Diets high in fat from vegetable and nonaquatic animal sources (rich in linoleic acid, an ω-6 fatty acid, and saturated fats) lead to insulin resistance. In rats fed high-fat diets, replacement of only 6 percent of the linoleic ω-6 fatty acids from safflower oil with long-chain polyunsaturated ω-3 fatty acids from fish oil prevented the development of insulin resistance. The effect was most pronounced in the liver and skeletal muscle, which have important roles in glucose supply and demand. The results may be important for therapy or prevention of non-insulin-dependent diabetes mellitus.
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Citations
Cites
The Inverse Relation between Fish Consumption and 20-Year Mortality from Coronary Heart Disease
Kromhout, D., Bosschieter, E. B., & Coulander, C. D. L. (1985) · New England Journal of Medicine · doi:10.1056/nejm198505093121901 · Cited by 2,177
Cited by
Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4318 · Cited by 2,164
The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension
Kaplan, N. M. (1989) · Archives of Internal Medicine · doi:10.1001/archinte.149.7.1514 · Cited by 1,516
Treatment of NAFLD with diet, physical activity and exercise
Romero-Gómez, M., Zelber-Sagi, S., & Trenell, M. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.05.016 · Cited by 1,347
Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diab.46.6.983 · Cited by 1,179
Self-citationDietary fats and prevention of type 2 diabetes
Risérus, U., Willett, W. C., & Hu, F. B. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2008.10.002 · Cited by 753
Metadata
- Authors
- Storlien, L. H., Kraegen, E. W., Chisholm, D. J., Ford, G. L., Bruce, D. G., & Pascoe, W. S.
- Venue
- Science
- Published
- 1987-08-21
- Volume
- 237
- Issue
- 4817
- Pages
- 885-888
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1975200587
- Cited by
- 650
- References
- 1
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Fish Oil Prevents Insulin Resistance Induced by High-Fat Feeding in Rats. https://app.cochat.ai/papers/10.1126/science.3303333
- The paper
- Storlien, L. H., Kraegen, E. W., Chisholm, D. J., Ford, G. L., Bruce, D. G., & Pascoe, W. S. (1987). Fish Oil Prevents Insulin Resistance Induced by High-Fat Feeding in Rats. Science. https://doi.org/10.1126/science.3303333
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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