The Inverse Relation between Fish Consumption and 20-Year Mortality from Coronary Heart Disease

Kromhout, Daan; Bosschieter, Edward B.; Coulander, Cor de Lezenne

doi:10.1056/nejm198505093121901

Cited by 2,177Fatty Acid Research and HealthNutritional Studies and DietCardiovascular Health and Risk Factors

The Inverse Relation between Fish Consumption and 20-Year Mortality from Coronary Heart Disease

Kromhout, Daan, Bosschieter, Edward B., Coulander, Cor de Lezenne·1985·New England Journal of Medicine

DOI 10.1056/nejm198505093121901

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Abstract

The low death rate from coronary heart disease among the Greenland Eskimos has been ascribed to their high fish consumption. We therefore decided to investigate the relation between fish consumption and coronary heart disease in a group of men in the town of Zutphen, the Netherlands. Information about the fish consumption of 852 middle-aged men without coronary heart disease was collected in 1960 by a careful dietary history obtained from the participants and their wives. During 20 years of follow-up 78 men died from coronary heart disease. An inverse dose-response relation was observed between fish consumption in 1960 and death from coronary heart disease during 20 years of follow-up. This relation persisted after multiple logistic-regression analyses. Mortality from coronary heart disease was more than 50 per cent lower among those who consumed at least 30 g of fish per day than among those who did not eat fish. We conclude that the consumption of as little as one or two fish dishes per week may be of preventive value in relation to coronary heart disease.

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Initial observational studies of Greenland Eskimos, Alaskan natives, and Japanese Okinawa islanders reported lower coronary artery disease death risk due to higher dietary fish intake.
“Initial observational studies, involving Greenland Eskimos, Alaskan natives, and Japanese Okinawa islanders, reported lower risk of coronary artery disease death in these populations due to higher dietary fish intake (10,40,65).”
From Trimethylamine N -Oxide, the Microbiome, and Heart and Kidney Disease (2017) · cites this paper as [65]

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Authors: Kromhout, D., Bosschieter, E. B., & Coulander, C. D. L.
Affiliations: Leiden University (NL)
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1985-05-09
Volume: 312
Issue: 19
Pages: 1205-1209
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm198505093121901
OpenAlex: W2325815717
Cited by: 2,177
References: 33
Citations by year: 2026: 2 · 2025: 4 · 2024: 9 · 2023: 23 · 2022: 29 · 2021: 23 · 2020: 37 · 2019: 28 · 2018: 26 · 2017: 31 · 2016: 32 · 2015: 33 · 2014: 44 · 2013: 44 · 2012: 43
FWCI: 92.95
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Public Health Service (HE 04697, HE 05471)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords: fish consumption, coronary artery disease, mortality, dose-response relationship, dietary history, middle-aged men, cardiovascular disease prevention, Greenland Eskimos
MeSH terms: Age Factors, Animals, Blood Pressure, Cholesterol, Coronary Disease, Diet, Feeding Behavior, Fishes, Humans, Longitudinal Studies, Male, Middle Aged, Netherlands, Regression Analysis, Smoking

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The Inverse Relation between Fish Consumption and 20-Year Mortality from Coronary Heart Disease

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