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Direct Demonstration of Macula Densa-Mediated Renin Secretion
Abstract
An in vitro method has been used to examine whether secretion of renin from the juxtaglomerular apparatus is affected by changes in the sodium chloride concentration of the tubular fluid at the macula densa. Single juxtaglomerular apparatuses were microdissected from rabbits and the tubule segment containing the macula densa was perfused, while simultaneously the entire juxtaglomerular apparatus was superfused, and the fluid was collected for renin measurement. In this preparation, in which influences from renal nerves and local hemodynamic effects are eliminated, a decrease in the tubular sodium chloride concentration at the macula densa results in a prompt stimulation of the renin release rate.
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Cited by
1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system
Li, Y. C., Kong, J., Wei, M., Chen, Z.-F., Liu, S. Q., & Cao, L.-P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215219 · Cited by 1,625
Classical Renin‐Angiotensin System in Kidney Physiology
Sparks, M. A., Crowley, S. D., Gurley, S. B., Mirotsou, M., & Coffman, T. M. (2014) · Comprehensive Physiology · doi:10.1002/cphy.c130040 · Cited by 521
Renal Autoregulation in Health and Disease
Carlström, M., Wilcox, C. S., & Arendshorst, W. J. (2015) · Physiological Reviews · doi:10.1152/physrev.00042.2012 · Cited by 485
Vallon, V., Mühlbauer, B., & Osswald, H. (2006) · Physiological Reviews · doi:10.1152/physrev.00031.2005 · Cited by 448
Regulation of renin: new evidence from cultured cells and genetically modified mice
Bader, M., & Ganten, D. (2000) · Journal of Molecular Medicine · doi:10.1007/s001090000089 · Cited by 80
Metadata
- Authors
- Skøtt, O., & Briggs, J. P.
- Venue
- Science
- Published
- 1987-09-25
- Volume
- 237
- Issue
- 4822
- Pages
- 1618-1620
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2083628730
- Cited by
- 215
- References
- 0
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Skøtt, O., & Briggs, J. P. (1987). Direct Demonstration of Macula Densa-Mediated Renin Secretion. Science. https://doi.org/10.1126/science.3306925
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
