The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
Evolutionary and Somatic Selection of the Antibody Repertoire in the Mouse
Abstract
The repertoire of antibody variable (V) regions has been subject to evolutionary selection, affecting both the diversity of V region genes in the germline and their expression in the B lymphocyte population and its subsets. In ontogeny, contact with an antigen leads to the expansion of B cells expressing antibodies complementary to it. In a defined phase of B cell differentiation, new sets of V regions are generated from the existing repertoire through somatic hypermutation. Cells carrying advantageous antibody mutants are selected into the memory compartment and produce a stable secondary response upon reexposure to the antigen.
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Citations
Cites
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Self-citation
Cited by
Diversity in the CDR3 Region of VH Is Sufficient for Most Antibody Specificities
Xu, J. L., & Davis, M. M. (2000) · Immunity · doi:10.1016/s1074-7613(00)00006-6 · Cited by 779
Directed Evolution: Methodologies and Applications
Wang, Y., Xue, P., Cao, M., Yu, T., Lane, S. T., & Zhao, H. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00260 · Cited by 719
Development of the Primary Antibody Repertoire
Alt, F. W., Blackwell, T. K., & Yancopoulos, G. D. (1987) · Science · doi:10.1126/science.3317825 · Cited by 615
The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry
Dominguez-Sola, D., Victora, G. D., Ying, C. Y., Phan, R. T., Saito, M., Nussenzweig, M. C., & Dalla-Favera, R. (2012) · Nature Immunology · doi:10.1038/ni.2428 · Cited by 490
Evolution of new nonantibody proteins via iterative somatic hypermutation
Wang, L., Jackson, W. C., Steinbach, P. A., & Tsien, R. Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407752101 · Cited by 416
Metadata
- Authors
- Rajewsky, K., Förster, I., & Cumano, A.
- Venue
- Science
- Published
- 1987-11-20
- Volume
- 238
- Issue
- 4830
- Pages
- 1088-1094
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2000107365
- Cited by
- 385
- References
- 77
- FWCI
- 11.23
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
