The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Molecular Basis for MHC Class II—Associated Autoimmunity
Abstract
Class II major histocompatibility (MHC) molecules have an immunoregulatory role. These cell-surface glycoproteins present fragments of protein antigens (or peptides) to thymus-derived lymphocytes (T cells). Nucleotide sequence polymorphism in the genes that encode the class II MHC products determines the specificity of the immune response and is correlated with the development of autoimmune diseases. This study identifies certain class II polymorphic amino acid residues that are strongly associated with susceptibility to insulin-dependent diabetes mellitus, rheumatoid arthritis, and pemphigus vulgaris. These findings implicate particular class II MHC isotypes in susceptibility to each disease and suggest new prophylactic and therapeutic strategies.
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Cites
Saiki, R. K., Scharf, S., Faloona, F., Mullis, K. B., Horn, G. T., Erlich, H. A., & Arnheim, N. (1985) · Science · doi:10.1126/science.2999980 · Cited by 8,956
Bjorkman, P. J., Saper, M. A., Samraoui, B., Bennett, W. S., Strominger, J. L., & Wiley, D. C. (1987) · Nature · doi:10.1038/329512a0 · Cited by 2,377
Cited by
Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1
Brown, J. H., Jardetzky, T. S., Gorga, J. C., Stern, L. J., Urban, R. G., Strominger, J. L., & Wiley, D. C. (1993) · Nature · doi:10.1038/364033a0 · Cited by 2,379
Anti-TNFα Therapy of Rheumatoid Arthritis: What Have We Learned?
Feldmann, M., & Maini, R. N. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.163 · Cited by 1,257
Finding genes that underlie complex traits.
Glazier, A. M., Nadeau, J. H., & Aitman, T. J. (2002) · Science · doi:10.1126/science.1076641 · Cited by 855
Lafaille, J. J., Nagashima, K., Katsuki, M., & Tonegawa, S. (1994) · Cell · doi:10.1016/0092-8674(94)90419-7 · Cited by 532
Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus
Kaufman, D. L., Erlander, M. G., Clare-Salzler, M., Atkinson, M. A., Maclaren, N. K., & Tobin, A. J. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115573 · Cited by 490
Metadata
- Authors
- Todd, J. A., Acha-Orbea, H., Bell, J. I., Chao, N., Fronek, Z., Jacob, C. O., McDermott, M., Sinha, A. A., Timmerman, L., Steinman, L., & McDevitt, H. O.
- Venue
- Science
- Published
- 1988-05-20
- Volume
- 240
- Issue
- 4855
- Pages
- 1003-1009
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1998531275
- Cited by
- 705
- References
- 2
- FWCI
- 45.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A Molecular Basis for MHC Class II—Associated Autoimmunity. https://app.cochat.ai/papers/10.1126/science.3368786
- The paper
- Todd, J. A., Acha-Orbea, H., Bell, J. I., Chao, N., Fronek, Z., Jacob, C. O., McDermott, M., Sinha, A. A., Timmerman, L., Steinman, L., & McDevitt, H. O. (1988). A Molecular Basis for MHC Class II—Associated Autoimmunity. Science. https://doi.org/10.1126/science.3368786
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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