Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus
Open accessAbstract
Insulin-dependent diabetes mellitus (IDDM) is thought to result from the autoimmune destruction of the insulin-producing beta cells of the pancreas. Years before IDDM symptoms appear, we can detect autoantibodies to one or both forms of glutamate decarboxylase (GAD65 and GAD67), synthesized from their respective cDNAs in a bacterial expression system. Individual IDDM sera show distinctive profiles of epitope recognition, suggesting different humoral immune responses. Although the level of GAD autoantibodies generally decline after IDDM onset, patients with IDDM-associated neuropathies have high levels of antibodies to GAD, years after the appearance of clinical IDDM. We note a striking sequence similarity between the two GADs and Coxsackievirus, a virus that has been associated with IDDM both in humans and in experimental animals. This similarity suggests that molecular mimicry may play a role in the pathogenesis of IDDM.
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GAD65 and GAD67 are major auto-antigens in type-1 diabetes.
“GAD65 and GAD67 are major auto-antigens in type-1 diabetes (343, 599).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [343]
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Cites
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719 · see citing works
Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes
Studier, F. W., & Moffatt, B. A. (1986) · Journal of Molecular Biology · doi:10.1016/0022-2836(86)90385-2 · Cited by 6,372 · see citing works
The scanning model for translation: an update.
Kozak, M. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.108.2.229 · Cited by 3,485 · see citing works
Baekkeskov, S., Aanstoot, H.-J., Christgai, S., Reetz, A., Solimena, M., Cascalho, M., Folli, F., Richter-Olesen, H., & Camilli, P.-D. (1990) · Nature · doi:10.1038/347151a0 · Cited by 1,964 · see citing works
ROLE OF ABERRANT HLA-DR EXPRESSION AND ANTIGEN PRESENTATION IN INDUCTION OF ENDOCRINE AUTOIMMUNITY
Bottazzo, G., Hanafusa, T., Pujol‐Borrell, R., & Feldmann, M. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90629-3 · Cited by 1,254 · see citing works
Two genes encode distinct glutamate decarboxylases
Erlander, M. G., Tillakaratne, N. J. K., Feldblum, S., Patel, N., & Tobin, A. J. (1991) · Neuron · doi:10.1016/0896-6273(91)90077-d · Cited by 1,213 · see citing works
Self-citationVirus-Induced Diabetes Mellitus
Yoon, J., Austin, M., Onodera, T., & Notkins, A. L. (1979) · New England Journal of Medicine · doi:10.1056/nejm197905243002102 · Cited by 1,017 · see citing works
Molecular mimicry and autoimmune disease
Oldstone, M. B. A. (1987) · Cell · doi:10.1016/0092-8674(87)90507-1 · Cited by 932 · see citing works
Kaufman, D. L., Houser, C. R., & Tobin, A. J. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb08211.x · Cited by 789 · see citing works
Self-citationA Molecular Basis for MHC Class II—Associated Autoimmunity
Todd, J. A., Acha‐Orbea, H., Bell, J. I., Chao, N. J. A., Fronek, Z., Jacob, C. O., McDermott, M., Sinha, A. A., Timmerman, L., Steinman, L., et al. (1988) · Science · doi:10.1126/science.3368786 · Cited by 703 · see citing works
Type-I diabetes: a chronic autoimmune disease of human, mouse, and rat
Castano, L., & Eisenbarth, G. S. (1990) · Annual Review of Immunology · doi:10.1146/annurev.iy.08.040190.003243 · Cited by 644 · see citing works
Bækkeskov, S., Nielsen, J. H., Marner, B., Bilde, T., Ludvigsson, J., & Lernmark, Å. (1982) · Nature · doi:10.1038/298167a0 · Cited by 530 · see citing works
Immunology: The ins and outs of antigen processing and presentations
Germain, R. N. (1986) · Nature · doi:10.1038/322687a0 · Cited by 498 · see citing works
Autoimmune Diseases: The Failure of Self Tolerance
Sinha, A. A., Lopez, M. T., & McDevitt, H. O. (1990) · Science · doi:10.1126/science.1972595 · Cited by 495 · see citing works
Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels
Rorsman, P., Berggren, P., Bokvist, K. B., Ericson, H., Möhler, H., Östenson, C., & Smith, P. A. (1989) · Nature · doi:10.1038/341233a0 · Cited by 460 · see citing works
Epidemiologic Approach to the Etiology of Type I Diabetes Mellitus and Its Complications
Flier, J. S., Underhill, L. H., Królewski, A. S., Warram, J. H., Rand, L. I., & Kahn, C. R. (1987) · New England Journal of Medicine · doi:10.1056/nejm198711263172206 · Cited by 415 · see citing works
Characterization of the proteins purified with monoclonal antibodies to glutamic acid decarboxylase
Chang, Y., & Gottlieb, D. I. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-06-02123.1988 · Cited by 329 · see citing works
Brefeldin A implicates egress from endoplasmic reticulum in class I restricted antigen presentation
Nuchtern, J. G., Bonifacino, J. S., Biddison, W. E., et al. (1989) · Nature · doi:10.1038/339223a0 · Cited by 319 · see citing works
Bækkeskov, S., Landin, M., Kristensen, J. K., Srikanta, S., Bruining, G. J., Mandrup-Poulsen, T. R., de Beaufort, C. E., Soeldner, J. S., Eisenbarth, G. S., & Lindgren, F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112903 · Cited by 315 · see citing works
Riley, W. J., Maclaren, N. K., Krischer, J. P., Spillar, R. P., Silverstein, J. H., Schatz, D., Schwartz, S., Malone, J. I., Shah, S., Vadheim, C. M., et al. (1990) · New England Journal of Medicine · doi:10.1056/nejm199010253231704 · Cited by 284 · see citing works
Self-citationγ‐Aminobutyric Acid Outside the Mammalian Brain
Erdö, S. L., & Wolff, J. R. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb01882.x · Cited by 261 · see citing works
Brain Glutamate Decarboxylase Cloned in λgt-11: Fusion Protein Produces γ-Aminobutyric Acid
Kaufman, D. L., McGinnis, J. F., Krieger, N. R., & Tobin, A. J. (1986) · Science · doi:10.1126/science.3518061 · Cited by 260 · see citing works
Self-citationKing, M., Bidwell, D. E., Shaikh, A., Voller, A., & Banatvala, J. E. (1983) · The Lancet · doi:10.1016/s0140-6736(83)92353-x · Cited by 254 · see citing works
Pathology of Autonomic Neuropathy in Diabetes Mellitus
Duchen, L. W., ANJORIN, A., Watkins, P., & MACKAY, J. D. (1980) · Annals of Internal Medicine · doi:10.7326/0003-4819-92-2-301 · Cited by 247 · see citing works
Genetic control of autoimmunity in type 1 diabetes
Todd, J. A. (1990) · Immunology Today · doi:10.1016/0167-5699(90)90049-f · Cited by 236 · see citing works
The significance of the concordance rate for Type 1 (insulin-dependent) diabetes in identical twins
Olmos, P. R., A’Hern, R., Heaton, D., Millward, B. A., Risley, D., Pyke, D. A., & Leslie, R. D. G. (1988) · Diabetologia · doi:10.1007/bf00274777 · Cited by 219 · see citing works
Banatvala, J. E., Schernthaner, G.-H., Schober, E., et al. (1985) · The Lancet · doi:10.1016/s0140-6736(85)91843-4 · Cited by 214 · see citing works
64 000 Mr autoantibodies as predictors of insulin-dependent diabetes
Atkinson, M. A., Maclaren, N. K., Riley, W. J., Sharp, D., & Lacey, P. E. (1990) · The Lancet · doi:10.1016/0140-6736(90)91241-2 · Cited by 203 · see citing works
Self-citationJenkins, O. F., Booth, J. D., Minor, P. D., & Almond, J. W. (1987) · Journal of General Virology · doi:10.1099/0022-1317-68-7-1835 · Cited by 202 · see citing works
Kobayashi, Y., Kaufman, D. L., & Tobin, A. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-09-02768.1987 · Cited by 187 · see citing works
Self-citationGamble, D. R. (1980) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a036226 · Cited by 157 · see citing works
Bækkeskov, S., Dyrberg, T., & Lernmark, Å. (1984) · Science · doi:10.1126/science.6374896 · Cited by 146 · see citing works
Barrett-Connor, E. L. (1985) · Clinical Infectious Diseases · doi:10.1093/clinids/7.2.207 · Cited by 126 · see citing works
Oldstone, M. B. A. (1989) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-74594-2_11 · Cited by 118 · see citing works
Induction of diabetes by cumulative environmental insults from viruses and chemicals
Toniolo, A., Onodera, T., Yoon, J., & Notkins, A. L. (1980) · Nature · doi:10.1038/288383a0 · Cited by 101 · see citing works
Ziegler, A. G., Herskowitz, R. D., Jackson, R. A., Soeldner, J. S., & Eisenbarth, G. S. (1990) · Diabetes Care · doi:10.2337/diacare.13.7.762 · Cited by 97 · see citing works
Autoantibodies in Nonobese Diabetic Mice Immunoprecipitate 64,000-Mr Islet Antigen
Atkinson, M. A., & Maclaren, N. K. (1988) · Diabetes · doi:10.2337/diab.37.11.1587 · Cited by 83 · see citing works
Self-citationCoxsackie Virus B4 Produces Transient Diabetes in Nonhuman Primates
Yoon, J., London, W. T., Curfman, B. L., et al. (1986) · Diabetes · doi:10.2337/diab.35.6.712 · Cited by 81 · see citing works
Toniolo, A., Onodera, T., Jordan, G. W., et al. (1982) · Diabetes · doi:10.2337/diab.31.6.496 · Cited by 75 · see citing works
[Myocarditis and insulitis following coxsackie virus infection].
Gladisch, R., Hofmann, W., & Waldherr, R. (1976) · PubMed · Cited by 70 · see citing works
How, When, and Why to Predict IDDM
Maclaren, N. K. (1988) · Diabetes · doi:10.2337/diab.37.12.1591 · Cited by 47 · see citing works
Self-citationCoxsackie virus B4 produces transient diabetes in nonhuman primates
Yoon, J., London, W. T., Curfman, B. L., et al. (1986) · Diabetes · doi:10.2337/diabetes.35.6.712 · Cited by 41 · see citing works
Christie, M. R., PIPELEERS, D. G., Lernmark, Å., et al. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40240-8 · Cited by 37 · see citing works
Rabinowe, S. L., Brown, F. M., Watts, M., et al. (1989) · Diabetes Care · doi:10.2337/diacare.12.1.1 · Cited by 37 · see citing works
Gerling, I., Nejman, C., & Chatterjee, N. K. (1988) · Diabetes · doi:10.2337/diab.37.10.1419 · Cited by 37 · see citing works
Insulin-dependent (juvenile-onset, type 1) diabetes mellitus Coxsackie B viruses revisited.
Banatvala, J. E. (1987) · PubMed · Cited by 34 · see citing works
Initial Pathogenic Events in IDDM
Maclaren, N. K., Schatz, D., DRASH, A. L., et al. (1989) · Diabetes · doi:10.2337/diab.38.4.534 · Cited by 29 · see citing works
Self-citationChatterjee, N. K., Nejman, C., & Gerling, I. (1988) · Journal of Medical Virology · doi:10.1002/jmv.1890260109 · Cited by 18 · see citing works
How, when, and why to predict IDDM
Maclaren, N. K. (1988) · Diabetes · doi:10.2337/diabetes.37.12.1591 · Cited by 16 · see citing works
Self-citationPrevention of Type I Diabetes Mellitus
(1991) · Diabetes Care · doi:10.2337/diacare.14.2.14 · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- LaPorte, R., and K. Cruickshanks. 1988. Incidence and risk factors for insulin dependent diabetes mellitus. In Diabetes in America, National Diabetes Data Group. NIH Publication No. 85-1468. Chapter III, pp. 1-12.
Cited by
Sorted by citations
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (2003) · Diabetes Care · doi:10.2337/diacare.26.2007.s5 · Cited by 2,689 · see citing works
Sacks, D. B., Arnold, M., Bakris, G. L., Bruns, D. E., Horvath, A. R., Kirkman, M. S., Lernmark, A., Metzger, B. E., & Nathan, D. M. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2010.161596 · Cited by 1,360 · see citing works
Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793 · see citing works
Sacks, D. B., Arnold, M., Bakris, G. L., Bruns, D. E., Horvath, A. R., Kirkman, M. S., Lernmark, A., Metzger, B. E., & Nathan, D. M. (2011) · Diabetes Care · doi:10.2337/dc11-9998 · Cited by 718 · see citing works
Atkinson, M. A., Bowman, M. A., Campbell, L., Darrow, B. L., Kaufman, D. L., & Maclaren, N. K. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117567 · Cited by 448 · see citing works
Self-citationGrubin, C. E., Daniels, T., Toivola, B., Landin-Olsson, M., Hagopian, W. A., Li, L., Karlsen, A. E., Boel, E., Michelsen, B., & Lernmark, �. (1994) · Diabetologia · doi:10.1007/bf00408469 · Cited by 415 · see citing works
Hormones and the physiological architecture of life history evolution
Finch, C. E., & Rose, M. R. (1995) · The Quarterly Review of Biology · doi:10.1086/418864 · Cited by 376 · see citing works
Sacks, D. B., Arnold, M., Bakris, G. L., Bruns, D. E., Horvath, A. R., Lernmark, Å., Metzger, B. E., Nathan, D. M., & Kirkman, M. S. (2023) · Diabetes Care · doi:10.2337/dci23-0036 · Cited by 351 · see citing works
Islet cell autoantigens in insulin-dependent diabetes
Atkinson, M. A., & Maclaren, N. K. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116745 · Cited by 129 · see citing works
Self-citationMaclaren, N., Lan, M., Coutant, R., Schatz, D., Silverstein, J., Muir, A., Clare-Salzer, M., She, J.-X., Malone, J., Crockett, S., et al. (1999) · Journal of Autoimmunity · doi:10.1006/jaut.1999.0281 · Cited by 117 · see citing works
Self-citationThe aetiology of type 1 diabetes: an epidemiological perspective
Dahlquist, G. (1998) · Acta Paediatrica · doi:10.1111/j.1651-2227.1998.tb01244.x · Cited by 89 · see citing works
Basavalingappa, R. H., Arumugam, R., Lasrado, N., Yalaka, B., Massilamany, C., Gangaplara, A., Riethoven, J.-J., Xiang, S.-H., Steffen, D., & Reddy, J. (2020) · Molecular Immunology · doi:10.1016/j.molimm.2020.06.017 · Cited by 29 · see citing works
- Authors
- Kaufman, D. L., Erlander, M. G., Clare-Salzler, M., Atkinson, M. A., Maclaren, N. K., & Tobin, A. J.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1992-01-01
- Volume
- 89
- Issue
- 1
- Pages
- 283-292
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC442846
- OpenAlex
- W2154100983
- Cited by
- 490
- References
- 50
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 6 · 2023: 7 · 2022: 9 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 9 · 2015: 10 · 2014: 14 · 2013: 9 · 2012: 6
- FWCI
- 24.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- type 1 diabetes, glutamic acid decarboxylase, GAD65, GAD67, autoantibodies, autoimmunity, beta cell destruction, diabetic neuropathy, epitope recognition, molecular mimicry, Coxsackie virus
- MeSH terms
- Amino Acid Sequence, Epitopes, Autoantibodies, Autoantigens, Autonomic Nervous System, Diabetes Mellitus, Type 2, Diabetic Neuropathies, Enterovirus, Glutamate Decarboxylase, Humans, Islets of Langerhans, Isoenzymes, Molecular Sequence Data, Peptides, Sequence Homology, Nucleic Acid, Viral Proteins, Autoimmunity
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