Finding genes that underlie complex traits.

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

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The Structure of Haplotype Blocks in the Human Genome

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

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The Future of Genetic Studies of Complex Human Diseases

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Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

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Genetic Dissection of Complex Traits

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Evolution at Two Levels in Humans and Chimpanzees: Their macromolecules are so alike that regulatory mutations may account for their biological differences

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HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

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Searching for genetic determinants in the new millennium

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Hd1, a Major Photoperiod Sensitivity Quantitative Trait Locus in Rice, Is Closely Related to the Arabidopsis Flowering Time Gene CONSTANS

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Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

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fw2.2 : A Quantitative Trait Locus Key to the Evolution of Tomato Fruit Size

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Permutation Tests for Multiple Loci Affecting a Quantitative Character

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Positional Candidate Cloning of a QTL in Dairy Cattle: Identification of a Missense Mutation in the Bovine DGAT1 Gene with Major Effect on Milk Yield and CompositionPreprint

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Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage.

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Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats

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A Molecular Basis for MHC Class II—Associated Autoimmunity

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Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

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A genome–wide search for human non–insulin–dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2

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Modifier genes in mice and humans

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The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia

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Dissecting the architecture of a quantitative trait locus in yeast

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Apolipoprotein E is essential for amyloid deposition in the <i>APP</i> ^V717F transgenic mouse model of Alzheimer's disease

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Hd6 , a rice quantitative trait locus involved in photoperiod sensitivity, encodes the α subunit of protein kinase CK2

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Quantitative trait loci in Drosophila

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Dissecting Human Disease in the Postgenomic Era

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Association of NOD2 (CARD 15) genotype with clinical course of Crohn's disease: a cohort study

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Detection of regulatory variation in mouse genes

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Identification and Characterization of the Mouse Obesity Gene tubby: A Member of a Novel Gene Family

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A candidate gene for the mouse mutation tubby

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Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A β-chain or normal I-E α-chain

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Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis

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Prevention of autoimmune insulitis by expression of I–E molecules in NOD mice

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From QTL to gene: the harvest begins

Korstanje, R., & Paigen, B. J. (2002) · Nature Genetics · doi:10.1038/ng0702-235 · Cited by 243 · see citing works

Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping

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Parameters for reliable results in genetic association studies in common disease

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Genetic Protection from the Inflammatory Disease Type 1 Diabetes in Humans and Animal Models

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Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in non-obese diabetic mice

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Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats

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Cblb is a major susceptibility gene for rat type 1 diabetes mellitus

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Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats

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A QTL with major effect on milk yield and composition maps to bovine Chromosome 14

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Molecular Dissection of a Major Gene Effect on a Quantitative Trait: The Level of Alcohol Dehydrogenase Expression in Drosophila melanogaster

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Deletion of cytosolic phospholipase A 2 suppresses Apc Min -induced tumorigenesis

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A major effect QTL determined by multiple genes in epileptic EL mice.

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Microtubule-associated protein 1A is a modifier of tubby hearing (moth1)

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Haplotype Combinations of Calpain 10 Gene Polymorphisms Associate With Increased Risk of Impaired Glucose Tolerance and Type 2 Diabetes in South Indians

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CARD15 gene and the classification of Crohn's disease

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Cell-specific expression of tubby gene family members (tub, Tulp1,2, and 3) in the retina.

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Variation in Three Single Nucleotide Polymorphisms in the Calpain-10 Gene Not Associated With Type 2 Diabetes in a Large Finnish Cohort

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Functional screening of an asthma QTL in YAC transgenic mice

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Molecular basis of the Cd36 chromosomal deletion underlying SHR defects in insulin action and fatty acid metabolism

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“Gene‐Swap Knock‐in” Cassette in Mice to Study Allelic Differences in Human Genes

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A non-MHC locus essential for autoimmune type I diabetes in the Komeda Diabetes-Prone rat.

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Use of in vitro mutagenesis to analyze the molecular basis of the difference in Adh expression associated with the allozyme polymorphism in Drosophila melanogaster.

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Sensitized polygenic trait analysis

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The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions

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Walking the Interactome for Prioritization of Candidate Disease Genes

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Discovering Endophenotypes for Major Depression

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Mammalian circadian biology: elucidating genome-wide levels of temporal organization

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A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig

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BLINK: a package for the next level of genome-wide association studies with both individuals and markers in the millions

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Breeding for Yield Potential and Stress Adaptation in Cereals

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Linkage disequilibrium and association studies in higher plants: Present status and future prospects

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Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans

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The landscape of genetic complexity across 5,700 gene expression traits in yeast

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Domestic-animal genomics: deciphering the genetics of complex traits

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Most Rare Missense Alleles Are Deleterious in Humans: Implications for Complex Disease and Association Studies

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Mapping determinants of human gene expression by regional and genome-wide association

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To clone or not to clone plant QTLs: present and future challenges

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The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans

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Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease

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Improved Detection of Common Variants Associated with Schizophrenia by Leveraging Pleiotropy with Cardiovascular-Disease Risk Factors

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Microsatellites and their genomic distribution, evolution, function and applications: A review with special reference to fish genetics

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Strategies for mapping and cloning quantitative trait genes in rodents

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Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotide in affecting milk yield and composition

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Principles for the post-GWAS functional characterization of cancer risk loci

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The nature and identification of quantitative trait loci: a community's view

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Cardiovascular Disease

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The Molecular-Genetic Basis of Functional Hyperandrogenism and the Polycystic Ovary Syndrome

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Genome-wide inferring gene–phenotype relationship by walking on the heterogeneous network

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Searching for the Autoimmune Thyroid Disease Susceptibility Genes: From Gene Mapping to Gene Function

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A Genomic Pathway Approach to a Complex Disease: Axon Guidance and Parkinson Disease

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Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate

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Evolutionary and ecological functional genomics

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Identity by Descent: Variation in Meiosis, Across Genomes, and in Populations

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Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chromosome 6 affecting milk yield and composition in Holstein cattlePreprint

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Nucleotide Diversity and Linkage Disequilibrium in Cold-Hardiness- and Wood Quality-Related Candidate Genes in Douglas Fir

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Will the Genomics Revolution Revolutionize Psychiatry?

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Review of Quantitative Trait Loci Identified in the Chicken

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The Genetic Basis of Thyroid Autoimmunity

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REVIEW: GENETICS Finding Genes That Underlie Complex Traits

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Genetic Approaches to Studying Common Diseases and Complex Traits

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PROCEEDINGS Open Access

Sun, Y. V., Zhao, W., Shedden, K. A., & Kardia, S. L. (2016)

Complex Diseases: Research, Applications and SolutionsPreprint

Cebo, D., Francs, M., La-Renzo, A., & Chukwunweike, O. N. (2019) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.13140/rg.2.2.11540.35205

Genetics of Complex Disease

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