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Cancer Immunotherapy
Abstract
This year marks a turning point in cancer, as long-sought efforts to unleash the immune system against tumors are paying off—even if the future remains a question mark.
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“Given that CRISPR-Cas9 has been applied in T cell modification 70 and immune modulation, 70 71”
From CRISPR-Cas9: a new and promising player in gene therapy (2015) · cites this paper as [70]
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Xu, X., Liu, A., Liu, S., Ma, Y., Zhang, X., Zhang, M., Zhao, J.-H., Sun, S., & Sun, X. J. (2023) · Biomaterials Research · doi:10.1186/s40824-023-00386-7 · Cited by 67
“Tumor immunotherapy can effectively eradicate primary and metastatic tumors and inhibit tumor via the anti-tumor immune response produced by the host cells [194, 195].”
BackgroundOverexpressed oncogenic tumor-self antigens
Bright, R. K., Bright, J. D., & Byrne, J. A. (2014) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.29475 · Cited by 70
“This promise is now being realized by FDA approval of two of the newest treatments for prostate cancer and melanoma, Sipuleucel T and CTLA-4 blockade.(3,8) Both of these immunotherapies rely on eliciting T cell-mediated immunity which requires antigen recognition and specificity.”
T-Cell Immunotherapy: Looking Forward
Corrigan‐Curay, J., Kiem, H., Baltimore, D., O’Reilly, M., Brentjens, R. J., Cooper, L. J. N., Forman, S. J., Gottschalk, S. M., Greenberg, P. D., Junghans, R. P., et al. (2014) · Molecular Therapy · doi:10.1038/mt.2014.148 · Cited by 65
Nouri, F., Sadeghpour, H., Heidari, R., & Dehshahri, A. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s140734 · Cited by 65
Vacchelli, E., Aranda, F., Obrist, F., Eggermont, A. M. M., Galon, J., Cremer, I., Zitvogel, L., Kroemer, G., & Galluzzi, L. (2014) · OncoImmunology · doi:10.4161/onci.29030 · Cited by 64
PD-L1 expression and its relationship with oncogenic drivers in non-small cell lung cancer (NSCLC)
Jiang, L., Su, X., Zhang, T., Yin, X., Zhang, M., Fu, H., Han, H., Sun, Y., Dong, L., Qian, J., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15839 · Cited by 69
Immunotherapy for Hepatocellular Carcinoma: Current Advances and Future Expectations
Xie, Y., Xiang, Y., Sheng, J., Zhang, D., Yao, X., Yang, Y., & Zhang, X. (2018) · Journal of Immunology Research · doi:10.1155/2018/8740976 · Cited by 62
Metadata
- Authors
- Couzin-Frankel, J.
- Corresponding author
- Couzin-Frankel, Jennifer
- Venue
- Science
- Published
- 2013-12-20
- Volume
- 342
- Issue
- 6165
- Pages
- 1432-1433
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2209812019
- Cited by
- 2,051
- References
- 0
- Citations by year
- 2026: 34 · 2025: 100 · 2024: 133 · 2023: 154 · 2022: 172 · 2021: 215 · 2020: 220 · 2019: 197 · 2018: 206 · 2017: 206 · 2016: 138 · 2015: 169 · 2014: 103 · 2013: 2
- FWCI
- 73.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- cancer immunotherapy, tumor immunology, immune checkpoint inhibitors
- MeSH terms
- Ipilimumab, Antibodies, Antibodies, Monoclonal, Clinical Trials as Topic, Humans, Immunotherapy, Melanoma, Neoplasms, T-Lymphocytes, CTLA-4 Antigen
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