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Cancer Immunotherapy
Abstract
This year marks a turning point in cancer, as long-sought efforts to unleash the immune system against tumors are paying off—even if the future remains a question mark.
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“Given that CRISPR-Cas9 has been applied in T cell modification 70 and immune modulation, 70 71”
From CRISPR-Cas9: a new and promising player in gene therapy (2015) · cites this paper as [70]
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“The field is now investigating the role of novel approaches to be used either alone or in combination, such as (1) the blockade of lymphocyte activation gene 3 (LAG3), which normally stimulates Treg cells and inhibits CD8+ effector T cells through its interaction with MHC class II molecules and (2) T-cell membrane pro…”
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“Indeed, cancer immunotherapy is increasingly recognized as a "breakthrough" approach, one with the potential to offer long-term, durable responses to patients with advanced cancer (2).”
BackgroundStochastic modeling of tumor progression and immune evasion
George, J. T., & Levine, H. (2018) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2018.09.012 · Cited by 27
“However, there have been significant advances made most recently in targeted and immune therapeutic strategies (Couzin-Frankel, 2013).”
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Impact of N6-methyladenosine (m6A) modification on immunity
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Immunotherapy approaches for hematological cancers
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Dendritic cell-based vaccine for pancreatic cancer in Japan
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Metadata
- Authors
- Couzin-Frankel, J.
- Corresponding author
- Couzin-Frankel, Jennifer
- Venue
- Science
- Published
- 2013-12-20
- Volume
- 342
- Issue
- 6165
- Pages
- 1432-1433
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2209812019
- Cited by
- 2,051
- References
- 0
- Citations by year
- 2026: 34 · 2025: 100 · 2024: 133 · 2023: 154 · 2022: 172 · 2021: 215 · 2020: 220 · 2019: 197 · 2018: 206 · 2017: 206 · 2016: 138 · 2015: 169 · 2014: 103 · 2013: 2
- FWCI
- 73.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- cancer immunotherapy, tumor immunology, immune checkpoint inhibitors
- MeSH terms
- Ipilimumab, Antibodies, Antibodies, Monoclonal, Clinical Trials as Topic, Humans, Immunotherapy, Melanoma, Neoplasms, T-Lymphocytes, CTLA-4 Antigen
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