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Cancer Immunotherapy
Abstract
This year marks a turning point in cancer, as long-sought efforts to unleash the immune system against tumors are paying off—even if the future remains a question mark.
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“Given that CRISPR-Cas9 has been applied in T cell modification 70 and immune modulation, 70 71”
From CRISPR-Cas9: a new and promising player in gene therapy (2015) · cites this paper as [70]
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“The most successful approaches have utilized either adoptive T-cell transfer or inhibition of immune checkpoints, such as CTLA-4 andPD-1/PDL1/2, which free antitumor T cells from the immunologic brakes expressed by the tumor cells or by other cells in the tumor microenvironment (42, 46, 47).”
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“Introduction Immunotherapy has revolutionized cancer care (1, 2).”
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“Complete therapy (4 courses) of Ipilimumab (Yervoy ) for the treatment of melanoma, for instance, costs $120 000 (Couzin-Frankel, 2013).”
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Immunotherapy for pancreatic cancer: A long and hopeful journey
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Selective Targeting of Glioblastoma with EGFRvIII/EGFR Bitargeted Chimeric Antigen Receptor T Cell
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“Chimeric antigen receptor (CAR)–engineered T (CAR T) cells are a promising strategy for cancer treatment (7).”
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Molecular imaging to enlighten cancer immunotherapies and underlying involved processes
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Rationale of Immunotherapy in Hepatocellular Carcinoma and Its Potential Biomarkers
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Metadata
- Authors
- Couzin-Frankel, J.
- Corresponding author
- Couzin-Frankel, Jennifer
- Venue
- Science
- Published
- 2013-12-20
- Volume
- 342
- Issue
- 6165
- Pages
- 1432-1433
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2209812019
- Cited by
- 2,051
- References
- 0
- Citations by year
- 2026: 34 · 2025: 100 · 2024: 133 · 2023: 154 · 2022: 172 · 2021: 215 · 2020: 220 · 2019: 197 · 2018: 206 · 2017: 206 · 2016: 138 · 2015: 169 · 2014: 103 · 2013: 2
- FWCI
- 73.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- cancer immunotherapy, tumor immunology, immune checkpoint inhibitors
- MeSH terms
- Ipilimumab, Antibodies, Antibodies, Monoclonal, Clinical Trials as Topic, Humans, Immunotherapy, Melanoma, Neoplasms, T-Lymphocytes, CTLA-4 Antigen
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