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Mesoderm Induction in Amphibians: the Role of TGF-β2-Like Factors
Abstract
Mesoderm induction in the amphibian embryo can be studied by exposing animal region explants (destined to become ectoderm) to appropriate stimuli and assaying the appearance of mesodermal products like α-actin messenger RNA. Transforming growth factor β2 (TGF-β2), but not TGF-β1, was active in α-actin induction, while addition of fibroblast growth factor had a small synergistic effect. Medium conditioned by Xenopus XTC cells (XTC-CM), known to have powerful mesoderm-inducing activity, was shown to contain TGF-β-like activity as measured by a radioreceptor binding assay, colony formation in NRK cells, and growth inhibition in CCL64 cells. The activity of XTC-CM in mesoderm induction and in growth inhibition of CCL64 cells was inhibited partially by antibodies to TGF-β2 but not by antibodies to TGF-β1. Thus, a TGF-β2-like molecule may be involved in mesoderm induction.
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Cited by
TGF-β and the TGF-β family: context-dependent roles in cell and tissue physiology
Morikawa, M., Derynck, R., & Miyazono, K. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021873 · Cited by 1,321
Amaya, E., Musci, T. J., & Kirschner, M. W. (1991) · Cell · doi:10.1016/0092-8674(91)90616-7 · Cited by 1,085
FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER
Harland, R., & Gerhart, J. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.611 · Cited by 839
Lyons, K. M., Pelton, R. W., & Hogan, B. L. (1989) · Genes & Development · doi:10.1101/gad.3.11.1657 · Cited by 438
Lehnert, S. A., & Akhurst, R. J. (1988) · Development · doi:10.1242/dev.104.2.263 · Cited by 342
Metadata
- Authors
- Rosa, F., Roberts, A. B., Danielpour, D., Dart, L. L., Sporn, M. B., & Dawid, I. B.
- Venue
- Science
- Published
- 1988-02-12
- Volume
- 239
- Issue
- 4841
- Pages
- 783-785
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2064185923
- Cited by
- 449
- References
- 0
- FWCI
- 33.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rosa, F., Roberts, A. B., Danielpour, D., Dart, L. L., Sporn, M. B., & Dawid, I. B. (1988). Mesoderm Induction in Amphibians: the Role of TGF-β2-Like Factors. Science. https://doi.org/10.1126/science.3422517
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