The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Inhibition of Endothelial Regeneration by Type-Beta Transforming Growth Factor from Platelets
Abstract
Damage to the vessel wall is a signal for endothelial migration and replication and for platelet release at the site of injury. Addition of transforming growth factor-beta (TGF-β) purified from platelets to growing aortic endothelial cells inhibited [ 3 H]thymidine incorporation in a concentration-dependent manner. A transient inhibition of DNA synthesis was also observed in response to wounding; cell migration and replication are inhibited during the first 24 hours after wounding. By 48 hours after wounding both TGF-β-treated and -untreated cultures showed similar responses. Flow microfluorimetric analysis of cell cycle distribution indicated that after 24 hours of exposure to TGF-β the cells were blocked from entering S phase, and the fraction of cells in G 1 was increased. The inhibition of the initiation of regeneration by TGF-β could allow time for recruitment of smooth muscle cells into the site of injury by other platelet components.
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Citations
Cites
An Algorithm for Least-Squares Estimation of Nonlinear Parameters
Marquardt, D. W. (1963) · Journal of the Society for Industrial and Applied Mathematics · doi:10.1137/0111030 · Cited by 30,728
Cited by
Folkman, J., & Klagsbrun, M. (1987) · Science · doi:10.1126/science.2432664 · Cited by 3,491
Tonnesen, M. G., Feng, X., & Clark, R. A. F. (2000) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1046/j.1087-0024.2000.00014.x · Cited by 1,463
Bussolino, F., Di Renzo, M. F., Ziche, M., Bocchietto, E., Olivero, M., Naldini, L., Gaudino, G., Tamagnone, L., Coffer, A., & Comoglio, P. M. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.629 · Cited by 1,337
Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice
Dickson, M. C., Martin, J. S., Cousins, F. M., Kulkarni, A. B., Karlsson, S., & Akhurst, R. J. (1995) · Development · doi:10.1242/dev.121.6.1845 · Cited by 1,029
TGF-β1 Signaling and Tissue Fibrosis
Kim, K. K., Sheppard, D., & Chapman, H. A. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022293 · Cited by 800
Metadata
- Authors
- Heimark, R. L., Twardzik, D. R., & Schwartz, S. M.
- Venue
- Science
- Published
- 1986-09-05
- Volume
- 233
- Issue
- 4768
- Pages
- 1078-1080
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1999340769
- Cited by
- 431
- References
- 1
- FWCI
- 10.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Heimark, R. L., Twardzik, D. R., & Schwartz, S. M. (1986). Inhibition of Endothelial Regeneration by Type-Beta Transforming Growth Factor from Platelets. Science. https://doi.org/10.1126/science.3461562
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
