The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Reversible Inhibition of Mammary Gland Growth by Transforming Growth Factor-β
Abstract
Transforming growth factor-β (TGF-β) can stimulate or inhibit growth of cells in vitro, as well as induce the transformed phenotype. Although widely distributed in animal tissue, the effects of TGF-β in vivo are largely unknown, and a physiological role for the peptide hormone has not been demonstrated. The effect of TGF-β on developing epithelial tissue in situ was studied by using slow-release plastic pellets containing TGF-β to treat developing mouse mammary gland. Powerful inhibition of mammary growth and morphogenesis was observed. This growth-inhibited mammary tissue was histologically normal, and the inhibitory effect was fully reversible. Under the conditions of these experiments, TGF-β displayed many of the characteristics expected of a physiologically active growth-regulatory molecule.
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Cites
Ignotz, R. A., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35666-1 · Cited by 2,492
Cited by
Langer, R. (1990) · Science · doi:10.1126/science.2218494 · Cited by 1,778
TGF-β and the TGF-β family: context-dependent roles in cell and tissue physiology
Morikawa, M., Derynck, R., & Miyazono, K. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021873 · Cited by 1,321
TGF‐β promotes cell death and suppresses lactation during the second stage of mammary involution
Bierie, B., Gorska, A. E., Stover, D. G., & Moses, H. L. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21646 · Cited by 39
Ciccarelli, E. J., Wing, Z., Bendelstein, M., Johal, R. K., Singh, G., Monas, A., & Savage-Dunn, C. (2024) · PLOS Genetics · doi:10.1371/journal.pgen.1011324 · Cited by 7
Cheng, J. D., & de Vellis, J. (2000) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(20000201)59:3<436::aid-jnr19>3.0.co;2-z
Metadata
- Authors
- Silberstein, G. B., & Daniel, C. W.
- Venue
- Science
- Published
- 1987-07-17
- Volume
- 237
- Issue
- 4812
- Pages
- 291-293
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1977797997
- Cited by
- 400
- References
- 1
- FWCI
- 8.98
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
