The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine.
Open accessAbstract
Castanospermine (1,6,7,8-tetrahydroxyoctahydroindolizine) is a plant alkaloid that modifies glycosylation by inhibiting alpha-glucosidase I. Castanospermine is shown to inhibit syncytium formation induced by the envelope glycoprotein of the human immunodeficiency virus and to inhibit viral replication. The decrease in syncytium formation in the presence of castanospermine can be attributed to inhibition of processing of the envelope precursor protein gp160, with resultant decreased cell surface expression of the mature envelope glycoprotein gp120. In addition, castanospermine may cause defects in steps involved in membrane fusion after binding of CD4 antigen. The antiviral effects of castanospermine may be due to modifications of the envelope glycoprotein that affect the ability of the virus to enter cells after attachment to the CD4 cell receptor.
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Popovic, M., Sarngadharan, M. G., Read, E., & Gallo, R. C. (1984) · Science · doi:10.1126/science.6200935 · Cited by 3,535
The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
Dalgleish, A. G., Beverley, P. C. L., Clapham, P. R., Crawford, D. H., Greaves, M. F., & Weiss, R. A. (1984) · Nature · doi:10.1038/312763a0 · Cited by 3,533
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Binding of HTLV-III/LAV to T4 + T Cells by a Complex of the 110K Viral Protein and the T4 Molecule
McDougal, J. S., Kennedy, M. S., Sligh, J. M., Cort, S. P., Mawle, A., & Nicholson, J. K. A. (1986) · Science · doi:10.1126/science.3001934 · Cited by 989
Functional Regions of the Envelope Glycoprotein of Human Immunodeficiency Virus Type 1
Kowalski, M., Potz, J., Basiripour, L., Dorfman, T., Goh, W. C., Terwilliger, E., Dayton, A., Rosen, C., Haseltine, W., & Sodroski, J. (1987) · Science · doi:10.1126/science.3629244 · Cited by 848
Self-citationRole of the HTLV-III/LAV envelope in syncytium formation and cytopathicity
Sodroski, J., Goh, W. C., Rosen, C., Campbell, K., & Haseltine, W. A. (1986) · Nature · doi:10.1038/322470a0 · Cited by 798
Self-citationImmunoglobulin gene transcription is activated by downstream sequence elements
Queen, C., & Baltimore, D. (1983) · Cell · doi:10.1016/0092-8674(83)90016-8 · Cited by 791
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Major Glycoprotein Antigens That Induce Antibodies in AIDS Patients Are Encoded by HTLV-III
Allan, J. S., Coligan, J. E., Barin, F., McLane, M. F., Sodroski, J. G., Rosen, C. A., Haseltine, W. A., Lee, T. H., & Essex, M. (1985) · Science · doi:10.1126/science.2986290 · Cited by 572
Self-citation
Cited by
Antiviral effects of an iminosugar derivative on flavivirus infections
Wu, S.-F., Lee, C.-J., Liao, C.-L., Dwek, R. A., Zitzmann, N., & Lin, Y.-L. (2002) · Journal of Virology · doi:10.1128/jvi.76.8.3596-3604.2002 · Cited by 220
Thin-layer chromatography with biological detection in phytochemistry
Marston, A. (2011) · Journal of Chromatography A · doi:10.1016/j.chroma.2010.12.068 · Cited by 220
HIV entry and envelope glycoprotein-mediated fusion
Blumenthal, R., Durell, S., & Viard, M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r112.406272 · Cited by 212
Fischer, P. B., Collin, M., Karlsson, G. B., James, W., Butters, T. D., Davis, S. J., Gordon, S., Dwek, R. A., & Platt, F. M. (1995) · Journal of Virology · doi:10.1128/jvi.69.9.5791-5797.1995 · Cited by 155
Therapeutic applications of iminosugars: Current perspectives and future opportunities
Horne, G., & Wilson, F. X. (2011) · Progress in medicinal chemistry · doi:10.1016/b978-0-12-381290-2.00004-5 · Cited by 87
Metadata
- Authors
- Walker, B. D., Kowalski, M., Goh, W. C., Kozarsky, K., Krieger, M., Rosen, C., Rohrschneider, L., Haseltine, W. A., & Sodroski, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-11
- Volume
- 84
- Issue
- 22
- Pages
- 8120-8124
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2001773708
- Cited by
- 337
- References
- 25
- FWCI
- 6.85
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine. https://app.cochat.ai/papers/10.1073/pnas.84.22.8120
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- Walker, B. D., Kowalski, M., Goh, W. C., Kozarsky, K., Krieger, M., Rosen, C., Rohrschneider, L., Haseltine, W. A., & Sodroski, J. (1987). Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.22.8120
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
