The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Dual Infection of the Central Nervous System by AIDS Viruses with Distinct Cellular Tropisms
Abstract
Human immunodeficiency virus (HIV) is the causative agent of the acquired immune deficiency syndrome (AIDS). A large number of AIDS patients show evidence of neurologic involvement, known as AIDS-related subacute encephalopathy, which has been correlated with the presence of HIV in the brain. In this study, two genetically distinct but related viruses were isolated from one patient from two different sources in the central nervous system: brain tissue and cerebrospinal fluid. Both viruses were found to replicate in peripheral blood lymphocytes, but only virus from brain tissue will efficiently infect macrophage/monocytes. The viruses also differ in their ability to infect a brain glioma explant culture. This infection of the brain-derived cells in vitro is generally nonproductive, and appears to be some form of persistent or latent infection. These results indicate that genetic variation of HIV in vivo may result in altered cell tropisms and possibly implicate strains of HIV with glial cell tropism in the pathogenesis of some neurologic disorders of AIDS.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Starcich, B. R., Hahn, B. H., Shaw, G. M., McNeely, P. D., Modrow, S., Wolf, H., Parks, E. S., Parks, W. P., Josephs, S. F., Gallo, R. C., et al. (1986) · Cell · doi:10.1016/0092-8674(86)90778-6 · Cited by 767
Cited by
Liu, R., Paxton, W. A., Choe, S., Ceradini, D., Martin, S. R., Horuk, R., MacDonald, M. E., Stuhlmann, H., Koup, R. A., & Landau, N. R. (1996) · Cell · doi:10.1016/s0092-8674(00)80110-5 · Cited by 3,074
Zack, J. A., Arrigo, S. J., Weitsman, S. R., Go, A. S., Haislip, A., & Chen, I. S. Y. (1990) · Cell · doi:10.1016/0092-8674(90)90802-l · Cited by 1,517
Self-citationCytokine-Induced Expression of HIV-1 in a Chronically Infected Promonocyte Cell Line
Folks, T. M., Justement, J., Kinter, A., Dinarello, C. A., & Fauci, A. S. (1987) · Science · doi:10.1126/science.3313729 · Cited by 905
Ochsenbauer, C., Edmonds, T. G., Ding, H., Keele, B. F., Decker, J., Salazar, M. G., Salazar-Gonzalez, J. F., Shattock, R., Haynes, B. F., Shaw, G. M., et al. (2012) · Journal of Virology · doi:10.1128/jvi.06157-11 · Cited by 342
Merrill, J. E., Koyanagi, Y., & Chen, I. S. (1989) · Journal of Virology · doi:10.1128/jvi.63.10.4404-4408.1989 · Cited by 332
Self-citation
Metadata
- Authors
- Koyanagi, Y., Miles, S., Mitsuyasu, R. T., Merrill, J. E., Vinters, H. V., & Chen, I. S. Y.
- Venue
- Science
- Published
- 1987-05-15
- Volume
- 236
- Issue
- 4803
- Pages
- 819-822
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2022770520
- Cited by
- 817
- References
- 1
- FWCI
- 11.47
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Dual Infection of the Central Nervous System by AIDS Viruses with Distinct Cellular Tropisms. https://app.cochat.ai/papers/10.1126/science.3646751
- The paper
- Koyanagi, Y., Miles, S., Mitsuyasu, R. T., Merrill, J. E., Vinters, H. V., & Chen, I. S. Y. (1987). Dual Infection of the Central Nervous System by AIDS Viruses with Distinct Cellular Tropisms. Science. https://doi.org/10.1126/science.3646751
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
