The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Interleukin-1 and tumor necrosis factor alpha can be induced from mononuclear phagocytes by human immunodeficiency virus type 1 binding to the CD4 receptor
Open accessAbstract
Cytokines such as interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha) are important in normal immune processes. In this study, we demonstrate that human immunodeficiency virus type 1 (HIV-1) virions induce normal peripheral blood mononuclear phagocytes to produce both IL-1 and TNF within a few hours after their exposure to virus. The induction of these cytokines by HIV-1 does not require a productive infection. Blocking studies with soluble CD4 indicate that the effect is mediated through the CD4 molecule. In addition, the treatment of mononuclear phagocytes with OKT4A monoclonal antibody mimics the effects of HIV-1. Thus, these results indicate that induction of IL-1 and TNF alpha can occur via signals mediated through the CD4 molecule on mononuclear phagocytes. TNF has been shown by other investigators to induce HIV-1 expression. Therefore, TNF alpha may play a role in autocrine and paracrine regulation of HIV-1 expression. In addition, the induction of IL-1 and TNF by HIV-1 may also contribute to some of the neurologic and physiologic disorders associated with acquired immunodeficiency syndrome.
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Cites
The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
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Self-citationTumor Necrosis Factor (Cachectin) as an Essential Mediator in Murine Cerebral Malaria
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Cited by
Hiscott, J., Marois, J., Garoufalis, J., D'Addario, M., Roulston, A., Kwan, I., Pepin, N., Lacoste, J., Nguyen, H., & Bensi, G. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6231 · Cited by 585
Buonaguro, L., Barillari, G., Chang, H. K., Bohan, C. A., Kao, V, Morgan, R., Gallo, R. C., & Ensoli, B. (1992) · Journal of Virology · doi:10.1128/jvi.66.12.7159-7167.1992 · Cited by 277
Metadata
- Authors
- Merrill, J. E., Koyanagi, Y., & Chen, I. S.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1989-10
- Volume
- 63
- Issue
- 10
- Pages
- 4404-4408
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1519144004
- Cited by
- 332
- References
- 34
- FWCI
- 6.28
- Type
- journal article
- Language
- en
- Open access
- green
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