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Cited by 184

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Cross-Regulatory Interactions Among Pair-Rule Genes in Drosophila

Harding, Katherine, Rushlow, Christine, Doyle, Helen J., Hoey, Timothy, Levine, Michael·1986·Science

Abstract

The pair-rule genes of Drosophila are required for the subdivision of the developing embryo into a repeating series of homologous body segments. One of the pair-rule genes, even-skipped ( eve ), appears to be particularly important for the overall segmentation pattern since eve - embryos lack all segmental subdivisions in the middle body region. On the basis of homeo box cross-homology we have isolated a gene, S72, which probably corresponds to eve . In embryo tissue sections S72 transcripts show a periodic distribution pattern. The eve - phenotype appears to involve altered patterns of fushi tarazu and engrailed expression. These and other findings suggest that pair-rule gene expression might involve hierarchical cross-regulatory interactions.

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Metadata

Authors
Harding, K., Rushlow, C., Doyle, H. J., Hoey, T., & Levine, M.
Venue
Science
Published
1986-08-29
Volume
233
Issue
4767
Pages
953-959
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1980712067
Cited by
184
References
1
FWCI
11.88
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Cross-Regulatory Interactions Among Pair-Rule Genes in Drosophila. https://app.cochat.ai/papers/10.1126/science.3755551
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Harding, K., Rushlow, C., Doyle, H. J., Hoey, T., & Levine, M. (1986). Cross-Regulatory Interactions Among Pair-Rule Genes in Drosophila. Science. https://doi.org/10.1126/science.3755551

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