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Catalytic Antibodies
Abstract
Monoclonal antibodies elicited to haptens that are analogs of the transition state for hydrolysis of carboxylic esters behaved as enzymic catalysts with the appropriate substrates. These substrates are distinguished by the structural congruence of both hydrolysis products with haptenic fragments. The haptens were potent inhibitors of this esterolytic activity, in agreement with their classification as transition state analogs. Mechanisms are proposed to account for the different chemical behavior of these antibodies with two types of ester substrates. The generation of an artificial enzyme through transition state stabilization by antibodies was thus demonstrated. These studies indicate a potentially general approach to catalyst design.
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Citations
Cited by
Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes
Wei, H., & Wang, E. (2013) · Chemical Society Reviews · doi:10.1039/c3cs35486e · Cited by 3,779
Dynamic Combinatorial Chemistry
Corbett, P. T., Leclaire, J., Vial, L., West, K. R., Wietor, J.-L., Sanders, J. K. M., & Otto, S. (2006) · Chemical Reviews · doi:10.1021/cr020452p · Cited by 1,922
Structural Biology and Chemistry of the Terpenoid Cyclases
Christianson, D. W. (2006) · Chemical Reviews · doi:10.1021/cr050286w · Cited by 788
At the Crossroads of Chemistry and Immunology: Catalytic Antibodies
Lerner, R. A., Benkovic, S. J., & Schultz, P. G. (1991) · Science · doi:10.1126/science.2024118 · Cited by 668
Self-citationMolecular Diversity Required for the Formation of Autocatalytic Sets
Hordijk, W., Steel, M., & Kauffman, S. A. (2019) · Life · doi:10.3390/life9010023 · Cited by 24
Metadata
- Authors
- Tramontano, A., Janda, K. D., & Lerner, R. A.
- Venue
- Science
- Published
- 1986-12-19
- Volume
- 234
- Issue
- 4783
- Pages
- 1566-1570
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W4253316735
- Cited by
- 605
- References
- 0
- FWCI
- 24.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tramontano, A., Janda, K. D., & Lerner, R. A. (1986). Catalytic Antibodies. Science. https://doi.org/10.1126/science.3787261
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