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Cellular and Subcellular Heterogeneity of [Ca 2+ ] i in Single Heart Cells Revealed by Fura-2
Abstract
Digital imaging of calcium indicator signals (fura-2 fluorescence) from single cardiac cells has revealed different subcellular patterns of cytoplasmic calcium ion concentration ([Ca 2+ ] i ) that are associated with different types of cellular appearance and behavior. In any population of enzymatically isolated rat heart cells, there are (i) mechanically quiescent cells in which [Ca 2+ ] i is spatially uniform, constant over time, and relatively low; (ii) spontaneously contracting cells, which have an increased [Ca 2+ ] i , but in which the spatial uniformity of [Ca 2+ ] i is interrupted periodically by spontaneous propagating waves of high [Ca 2+ ] i ; and (iii) cells that are hypercontracted (rounded up) and that have higher levels of [Ca 2+ ] i than the other two types. The observed cellular and subcellular heterogeneity of [Ca 2+ ] i in isolated cells indicates that experiments performed on suspensions of cells should be interpreted with caution. The spontaneous [Ca 2+ ] i fluctuations previously observed without spatial resolution in multicellular preparations may actually be inhomogeneous at the subcellular level.
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Cited by
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Cannell, M. B., Berlin, J. R., & Lederer, W. J. (1987) · Science · doi:10.1126/science.2446391 · Cited by 353
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Metadata
- Authors
- Wier, W. G., Cannell, M. B., Berlin, J. R., Marban, E., & Lederer, W. J.
- Venue
- Science
- Published
- 1987-01-16
- Volume
- 235
- Issue
- 4786
- Pages
- 325-328
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2168979459
- Cited by
- 347
- References
- 0
- FWCI
- 36.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wier, W. G., Cannell, M. B., Berlin, J. R., Marban, E., & Lederer, W. J. (1987). Cellular and Subcellular Heterogeneity of [Ca 2+ ] i in Single Heart Cells Revealed by Fura-2. Science. https://doi.org/10.1126/science.3798114
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