The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury
Abstract
The interleukins, which have a regulatory role in immune function, may also mediate inflammation associated with injury to the brain. In experiments to determine the effect of these peptide hormones on glial cell proliferation in culture, interleukin-1 was a potent mitogen for astroglia but had no effect on oligodendroglia. Interleukin-2 did not alter the growth of either type of glial cell. Activity similar to that of interleukin-1 was detected in brains of adult rats 10 days after the brains had been injured. These findings suggest that interleukin-1, released by inflammatory cells, may promote the formation of scars by astroglia in the damaged mammalian brain.
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Citations
Cites
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Galactocerebroside is a specific cell-surface antigenic marker for oligodendrocytes in culture
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Self-citation
Cited by
Microglia: a sensor for pathological events in the CNS
Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396
Secretory products of macrophages.
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Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.
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Fitch, M. T., & Silver, J. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2007.05.014 · Cited by 1,007
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Metadata
- Authors
- Giulian, D., & Lachman, L. B.
- Venue
- Science
- Published
- 1985-04-26
- Volume
- 228
- Issue
- 4698
- Pages
- 497-499
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2071394393
- Cited by
- 855
- References
- 21
- FWCI
- 29.79
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
