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Interleukin 1 stimulation of collagenase production by cultured fibroblasts.
Open accessAbstract
Interleukin 1 is a monokine that exerts biological effects on a variety of target cells in vitro. In this report, interleukin 1 has been found to be capable of stimulating collagenase production by cultured dermal fibroblasts. The concentrations of interleukin 1 that stimulate fibroblast collagenase production are similar to those that stimulate mouse thymocyte proliferation. Analyses by high performance liquid chromatography indicate that interleukin 1, rather than a contaminating monokine, is responsible for this effect on fibroblasts. Interleukin 1, released in vivo by macrophages infiltrating sites of tissue damage or inflammation, may function to stimulate the release of collagenase by connective tissue fibroblasts.
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Citations
Cited by
Secretory products of macrophages.
Nathan, C. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112815 · Cited by 2,615
Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury
Giulian, D., & Lachman, L. B. (1985) · Science · doi:10.1126/science.3872478 · Cited by 855
Self-citationBiomaterial biocompatibility and the macrophage
Anderson, J. M., & Miller, K. M. (1984) · Biomaterials · doi:10.1016/0142-9612(84)90060-7 · Cited by 403
Human monocyte/macrophage activation and interleukin 1 generation by biomedical polymers
Miller, K. M., & Anderson, J. M. (1988) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820220805 · Cited by 156
Miller, K. M., Rose‐Caprara, V., & Anderson, J. M. (1989) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820230904 · Cited by 84
Metadata
- Authors
- Postlethwaite, A. E., Lachman, L. B., Mainardi, C. L., & Kang, A. H.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1983-02-01
- Volume
- 157
- Issue
- 2
- Pages
- 801-806
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2144743138
- Cited by
- 368
- References
- 0
- FWCI
- 21.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Interleukin 1 stimulation of collagenase production by cultured fibroblasts. https://app.cochat.ai/papers/10.1084/jem.157.2.801
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- Postlethwaite, A. E., Lachman, L. B., Mainardi, C. L., & Kang, A. H. (1983). Interleukin 1 stimulation of collagenase production by cultured fibroblasts. The Journal of experimental medicine. https://doi.org/10.1084/jem.157.2.801
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.