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Cited by 368

The DOI matches its Crossref record.

Interleukin 1 stimulation of collagenase production by cultured fibroblasts.

Open access
Postlethwaite, A E, Lachman, L B, Mainardi, C L, Kang, A H·1983·The Journal of experimental medicine

Abstract

Interleukin 1 is a monokine that exerts biological effects on a variety of target cells in vitro. In this report, interleukin 1 has been found to be capable of stimulating collagenase production by cultured dermal fibroblasts. The concentrations of interleukin 1 that stimulate fibroblast collagenase production are similar to those that stimulate mouse thymocyte proliferation. Analyses by high performance liquid chromatography indicate that interleukin 1, rather than a contaminating monokine, is responsible for this effect on fibroblasts. Interleukin 1, released in vivo by macrophages infiltrating sites of tissue damage or inflammation, may function to stimulate the release of collagenase by connective tissue fibroblasts.

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Metadata

Authors
Postlethwaite, A. E., Lachman, L. B., Mainardi, C. L., & Kang, A. H.
Venue
The Journal of experimental medicine
Published
1983-02-01
Volume
157
Issue
2
Pages
801-806
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
OpenAlex
W2144743138
Cited by
368
References
0
FWCI
21.37
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Interleukin 1 stimulation of collagenase production by cultured fibroblasts. https://app.cochat.ai/papers/10.1084/jem.157.2.801
The paper
Postlethwaite, A. E., Lachman, L. B., Mainardi, C. L., & Kang, A. H. (1983). Interleukin 1 stimulation of collagenase production by cultured fibroblasts. The Journal of experimental medicine. https://doi.org/10.1084/jem.157.2.801

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.